Recombinant Human CA9 protein, His-Avi-tagged

Cat.No. : CA9-790H
Product Overview : Recombinant Human Carbonic Anhydrase IX/CA9 Protein is expressed from mammalian with a His Tag and Avi Tag at the C-terminal. It contains Gln 38-Asp 414.
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Description : CA9 is a member of the carbonic anhydrases' family, that is often expressed in cancer cells under hypoxic condition. CA9 expression potentially contributes to the regulation of cancer cell differentiation and mediates tumour-associated genes and signalling pathways, including apoptosis, hypoxia, G2M checkpoint, PI3K/AKR/mTOR signalling and TGF-beta signalling pathways.
Source : HEK293
Species : Human
Tag : His-Avi
Form : Supplied as 0.22um filtered solution in 50mM Tris,150mM NaCl PH 7.5.
Molecular Mass : The protein has a predicted MW of 43.7 kDa.Due to glycosylation, the protein migrates to 50-60 KDa based on Bis-Tris PAGE result.
Protein length : Gln 38-Asp 414
Endotoxin : Less than 0.05 EU per ug by the LAL method.
Purity : > 95% as determined by Bis-Tris PAGE
Storage : The product should be stored at -70°C. Please do not repeated freeze-thaw cycles
SDS-PAGE:
Gene Name : CA9 carbonic anhydrase 9 [Homo sapiens (human)]
Official Symbol : CA9
Synonyms : CA9; CAIX; CA-IX; Carbonate dehydratase IX; carbonic anhydrase 9; Carbonic Anhydrase IX; carbonic dehydratase; EC 4.2.1.1; G250; Membrane antigen MN; MN; P54/58N; PMW1; RCC; RCC-associated antigen G250; RCC-associated protein G250; Renal cell carcinoma-associated antigen G250
Gene ID : 768
mRNA Refseq : NM_001216.3
Protein Refseq : NP_001207.2
MIM : 603179
UniProt ID : Q16790

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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What signaling pathways are known to regulate CA9 expression? 06/15/2022

The HIF-1 signaling pathway primarily regulates CA9 in response to cellular oxygen levels.

How does CA9 contribute to pH regulation within the tumor microenvironment? 02/02/2022

CA9 aids in extracellular acidification, promoting tumor cell survival and invasion in acidic tumor microenvironments.

How is CA9 expression regulated in hypoxic conditions? 04/15/2021

CA9 expression is upregulated by the hypoxia-inducible factor (HIF) under low oxygen conditions.

How are elevated levels of CA9 associated with cancer prognosis? 05/26/2020

Elevated CA9 levels often correlate with poor prognosis in various cancers due to its role in tumor adaptation to hypoxia.

What post-translational modifications have been identified on CA9? 11/23/2017

Potential modifications like glycosylation can be identified using techniques like mass spectrometry.

Are there specific inhibitors that target CA9, especially in cancer therapeutics? 09/29/2017

Several inhibitors, like acetazolamide derivatives, have been explored to target CA9 in cancer treatment.

What roles does CA9 play in tumor physiology? 07/06/2017

CA9 helps tumors survive in hypoxic conditions by regulating pH through the conversion of CO2 to bicarbonate and protons.

Customer Reviews (3)

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Reviews
08/04/2022

    Exceptional consistency, vital for our research's reliability.

    12/16/2021

      Critical support for our protein analysis and quantification.

      02/07/2021

        Unmatched accuracy in protein identification and sequencing.

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