Recombinant Human CA9 Protein, His-tagged

Cat.No. : CA9-117H
Product Overview : Recombinant human CA9 protein with His tag was expressed in HEK293.
  • Specification
  • Gene Information
  • Related Products
  • Download
Description : Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA IX is a transmembrane protein and is one of only two tumor-associated carbonic anhydrase isoenzymes known. It is expressed in all clear-cell renal cell carcinoma, but is not detected in normal kidney or most other normal tissues. It may be involved in cell proliferation and transformation. This gene was mapped to 17q21.2 by fluorescence in situ hybridization, however, radiation hybrid mapping localized it to 9p13-p12.
Source : HEK293
Species : Human
Tag : His
Form : Lyophilized
Molecular Mass : 41.2 kDa
Protein Length : 459
AA Sequence : MAPLCPSPWLPLLIPAPAPGLTVQL LLSLLLLVPVHPQRLPRMQEDSPLG GGSSGEDDPLGEEDLPSEEDSPREE DPPGEEDLPGEEDLPGEEDLPEVKP KSEEEGSLKLEDLPTVEAPGDPQEP QNNAHRDKEGDDQSHWRYGGDPPWP RVSPACAGRFQSPVDIRPQLAAFCP ALRPLELLGFQLPPLPELRLRNNGH SVQLTLPPGLEMALGPGREYRALQL HLHWGAAGRPGSEHTVEGHRFPAEI HVVHLSTAFARVDEALGRPGGLAVL AAFLEEGPEENSAYEQLLSRLEEIA EEGSETQVPGLDISALLPSDFSRYF QYEGSLTTPPCAQGVIWTVFNQTVM LSAKQLHTLSDTLWGPGDSRLQLNF RATQPLNGRVIEASFPAGVDSSPRA AEPVQLNSCLAAGDILALVFGLLFA VTSVAFLVQMRRQHRRGTKGGVSYR PAEVAETGA
Purity : > 98%
Applications : WB; ELISA; FACS; FC
Stability : This bioreagent is stable at 4 centigrade (short-term) and -70 centigrade(long-term). After reconstitution, sample may be stored at 4 centigrade for 2-7 days and below -18 centigrade for future use.
Storage : At -20 centigrade.
Concentration : 1 mg/mL
Storage Buffer : PBS (pH 7.4-7.5). Sterile-filtered colorless solution.
Reconstitution : Reconstitute in sterile distilled H2O to no less than 100 μg/mL; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance.
Gene Name : CA9 carbonic anhydrase IX [ Homo sapiens (human) ]
Official Symbol : CA9
Synonyms : CA9; carbonic anhydrase IX; carbonic anhydrase 9; CAIX; carbonic dehydratase; MN; RCC associated protein G250; pMW1; CA-IX; P54/58N; membrane antigen MN; carbonate dehydratase IX; RCC-associated antigen G250; RCC-associated protein G250; renal cell carcinoma-associated antigen G250;
Gene ID : 768
mRNA Refseq : NM_001216
Protein Refseq : NP_001207
MIM : 603179
UniProt ID : Q16790

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Reviews
  • Q&As

Customer Reviews (3)

Write a review
Reviews
08/04/2022

    Exceptional consistency, vital for our research's reliability.

    12/16/2021

      Critical support for our protein analysis and quantification.

      02/07/2021

        Unmatched accuracy in protein identification and sequencing.

        Q&As (7)

        Ask a question
        What signaling pathways are known to regulate CA9 expression? 06/15/2022

        The HIF-1 signaling pathway primarily regulates CA9 in response to cellular oxygen levels.

        How does CA9 contribute to pH regulation within the tumor microenvironment? 02/02/2022

        CA9 aids in extracellular acidification, promoting tumor cell survival and invasion in acidic tumor microenvironments.

        How is CA9 expression regulated in hypoxic conditions? 04/15/2021

        CA9 expression is upregulated by the hypoxia-inducible factor (HIF) under low oxygen conditions.

        How are elevated levels of CA9 associated with cancer prognosis? 05/26/2020

        Elevated CA9 levels often correlate with poor prognosis in various cancers due to its role in tumor adaptation to hypoxia.

        What post-translational modifications have been identified on CA9? 11/23/2017

        Potential modifications like glycosylation can be identified using techniques like mass spectrometry.

        Are there specific inhibitors that target CA9, especially in cancer therapeutics? 09/29/2017

        Several inhibitors, like acetazolamide derivatives, have been explored to target CA9 in cancer treatment.

        What roles does CA9 play in tumor physiology? 07/06/2017

        CA9 helps tumors survive in hypoxic conditions by regulating pH through the conversion of CO2 to bicarbonate and protons.

        Ask a Question for All CA9 Products

        Required fields are marked with *

        My Review for All CA9 Products

        Required fields are marked with *

        0

        Inquiry Basket

        cartIcon
        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /
        • Service lnquiry:

        Stay Updated on the Latest Bioscience Trends