Recombinant Human CACNA2D2 Protein, GST-Tagged

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Recombinant Human CACNA2D2 Protein, GST-Tagged

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Cat.No. : CACNA2D2-0269H
Product Overview : Human CACNA2D2 partial ORF (NP_006021, 65 a.a. - 162 a.a.) recombinant protein with GST-tag at N-terminal.
Description : Calcium channels mediate the entry of calcium ions into the cell upon membrane polarization. This gene encodes the alpha-2/delta subunit of the voltage-dependent calcium channel complex. The complex consists of the main channel-forming subunit alpha-1, and auxiliary subunits alpha-2/delta, beta, and gamma. The auxiliary subunits function in the assembly and membrane localization of the complex, and modulate calcium currents and channel activation/inactivation kinetics. The subunit encoded by this gene undergoes post-translational cleavage to yield the extracellular alpha2 peptide and a membrane-anchored delta polypeptide. This subunit is a receptor for the antiepileptic drug, gabapentin. Mutations in this gene are associated with early infantile epileptic encephalopathy. Single nucleotide polymorphisms in this gene are correlated with increased sensitivity to opioid drugs. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2014]
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 36.52 kDa
AA Sequence : PQQHTMQHWA RRLEQEVDGV MRIFGGVQQL REIYKDNRNL FEVQENEPQK LVEKVAGDIE SLLDRKVQAL KRLADAAENF QKAHRWQDNI KEEDIVYY
Applications : Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Quality Control Testing :

12.5% SDS-PAGE Stained with Coomassie Blue.

Gene Name : CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2 [ Homo sapiens ]
Official Symbol : CACNA2D2
Synonyms : CACNA2D2; calcium channel, voltage-dependent, alpha 2/delta subunit 2; voltage-dependent calcium channel subunit alpha-2/delta-2; gene 26; KIAA0558; alpha 2 delta calcium channel subunit; voltage-gated calcium channel subunit alpha-2/delta-2; CACNA2D; LUAC11.1;
Gene ID : 9254
mRNA Refseq : NM_001005505
Protein Refseq : NP_001005505
MIM : 607082
UniProt ID : Q9NY47

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