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Recombinant Human CADM1 Protein, MYC/DDK-tagged, C13 and N15-labeled

Cat.No. : CADM1-428H
Product Overview : CADM1 MS Standard C13 and N15-labeled recombinant protein (NP_055148) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.
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Description : Mediates homophilic cell-cell adhesion in a Ca2+-independent manner. Also mediates heterophilic cell-cell adhesion with CADM3 and NECTIN3 in a Ca2+-independent manner. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM1 in vivo. In mast cells, may mediate attachment to and promote communication with nerves. CADM1, together with MITF, is essential for development and survival of mast cells in vivo. By interacting with CRTAM and thus promoting the adhesion between CD8+ T-cells and CD8+ dendritic cells, regulates the retention of activated CD8+ T-cell within the draining lymph node. Required for the intestinal retention of intraepithelial CD4+ CD8+ T-cells and, to a lesser extent, intraepithelial and lamina propria CD8+ T-cells and CD4+ T-cells. Interaction with CRTAM promotes the adhesion to gut-associated CD103+ dendritic cells, which may facilitate the expression of gut-homing and adhesion molecules on T-cells and the conversion of CD4+ T-cells into CD4+ CD8+ T-cells. Acts as a synaptic cell adhesion molecule and plays a role in the formation of dendritic spines and in synapse assembly. May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa. Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. May contribute to the less invasive phenotypes of lepidic growth tumor cells).
Source : HEK293
Species : Human
Tag : Myc/DDK
Molecular Mass : 48.3 kDa
AA Sequence : MASVVLPSGSQCAAAAAAAAPPGLR LRLLLLLFSAAALIPTGDGQNLFTK DVTVIEGEVATISCQVNKSDDSVIQ LLNPNRQTIYFRDFRPLKDSRFQLL NFSSSELKVSLTNVSISDEGRYFCQ LYTDPPQESYTTITVLVPPRNLMID IQKDTAVEGEEIEVNCTAMASKPAT TIRWFKGNTELKGKSEVEEWSDMYT VTSQLMLKVHKEDDGVPVICQVEHP AVTGNLQTQRYLEVQYKPQVHIQMT YPLQGLTREGDALELTCEAIGKPQP VMVTWVRVDDEMPQHAVLSGPNLFI NNLNKTDNGTYRCEASNIVGKAHSD YMLYVYDPPTTIPPPTTTTTTTTTT TTTILTIITDSRAGEEGSIRAVDHA VIGGVVAVVVFAMLCLLIILGRYFA RHKGTYFTHEAKGADDAADADTAII NAEGGQNNSEEKKEYFITRTRPLEQ KLISEEDLAANDILDYKDDDDKV
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 3 months from receipt of products under proper storage and handling conditions.
Storage : Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
Concentration : 50 μg/mL as determined by BCA
Storage Buffer : 100 mM glycine, 25 mM Tris-HCl, pH 7.3.
Gene Name : CADM1 cell adhesion molecule 1 [ Homo sapiens (human) ]
Official Symbol : CADM1
Synonyms : CADM1; cell adhesion molecule 1; IGSF4, immunoglobulin superfamily, member 4, TSLC1, tumor suppressor in lung cancer 1; BL2; IGSF4A; Necl 2; NECL2; nectin like 2; RA175; ST17; SYNCAM; SYNCAM1; TSLC-1; nectin-like 2; nectin-like protein 2; truncated CADM1 protein; TSLC1/Nectin-like 2/IGSF4; synaptic cell adhesion molecule; tumor suppressor in lung cancer 1; immunoglobulin superfamily member 4; immunoglobulin superfamily, member 4; spermatogenic immunoglobulin superfamily; immunoglobulin superfamily, member 4D variant 2; IGSF4; TSLC1; Necl-2; sgIGSF; sTSLC-1; synCAM1; MGC51880; MGC149785; DKFZp686F1789;
Gene ID : 23705
mRNA Refseq : NM_014333
Protein Refseq : NP_055148
MIM : 605686
UniProt ID : Q9BY67

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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How do genetic variations or mutations in the CADM1 gene affect its function, and what are the medical implications of these variations in diseases such as autism spectrum disorders and cancer? 01/31/2022

Mutations or genetic variations in CADM1 can lead to altered protein function, potentially contributing to the development of diseases like autism spectrum disorders and various cancers. Studying these variations helps uncover their specific roles in disease progression.

What is the role of CADM1 in cell adhesion, and how does it contribute to cellular processes in various tissues? 10/01/2021

CADM1 is a cell adhesion molecule that plays a crucial role in maintaining tissue integrity and mediating cell-cell adhesion. It is involved in various cellular processes, including tissue development, immune response, and neural cell connectivity.

Can you discuss the post-translational modifications of CADM1 and their relevance in cell signaling pathways and disease contexts? 05/08/2021

Post-translational modifications of CADM1, such as phosphorylation and glycosylation, play critical roles in modulating its interactions and functions. Understanding these modifications is important for unraveling disease mechanisms and potential therapeutic targets.

How does CADM1 contribute to the regulation of immune responses, particularly in the context of autoimmune diseases and immune cell interactions? 10/10/2019

CADM1 mediates immune cell interactions and regulates immune responses. Dysregulation of CADM1 has been implicated in autoimmune diseases like multiple sclerosis, where it affects immune cell adhesion and migration.

What are the current therapeutic approaches targeting CADM1 in cancer treatment, and what challenges exist in developing CADM1-specific therapies for clinical use? 02/14/2018

Therapeutic strategies targeting CADM1 in cancer treatment include antibody-based therapies and small molecule inhibitors. Challenges include ensuring specificity and minimizing potential side effects, given the diverse roles of CADM1 in different tissues.

Customer Reviews (3)

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06/09/2021

    Good quality - it's an essential part of our research.

    05/17/2019

      I highly recommend this product!

      06/09/2018

        Friendly services!

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