Recombinant Human Carnitine O-octanoyltransferase, GST-tagged, Active

• Cat.No.: CROT-287H
• Product Overview: Recombinant human COT (30-397) was expressed by baculovirus inSf9 insect cellsusing an N-terminal GST tag. MW= 70 kDa.

Specification

• Species: Human
• Source: Sf9 Cells
• Tag: GST
• Protein Length: 30-397 a.a.
• Description: COT is an oncogene that can activate both the MAP kinase and JNK kinase pathways. COT activates IkappaB kinases and induces the nuclear production of NF-kappaB. C-terminal catalytic domain of KSR2 associates with COT and KSR2 can negatively regulates the kinase activity of COT in vitro. Co-transfection of KSR2 with COT in cells lead to reduced COT-mediated ERK activation and COT-induced IL8 production in a dose-dependent manner.
• Sequence: 30-397.
• Applications: Kinase Assay, Western Blot.
• Storage And Stability: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Information

• Gene Name: CROT carnitine O-octanoyltransferase [ Homo sapiens ]
• Synonyms: CROT; carnitine O-octanoyltransferase; COT; peroxisomal carnitine acyltransferase; peroxisomal carnitine octanoyltransferase; EC 2.3.1.137
• Gene ID: 54677
• mRNA Refseq: NM_001143935
• Protein Refseq: NP_001137407
• MIM: 606090
• UniProt ID: Q9UKG9
• Chromosome Location: 7q21
• Pathway: Metabolism of lipids and lipoproteins
• Function: acyltransferase activity; carnitine O-octanoyltransferase activity; transferase activity