Recombinant Human CASR Protein (Tyr20-Lys601), C-6×His-tagged

• Cat.No.: CASR-01H
• Product Overview: Recombinant Human Calcium-sensing R/CaSR protein (Tyr20-Lys601) with a C-terminal 6×His tag was expressed in Human embryonic kidney cell, HEK293.

Specification

• Description: The protein encoded by this gene is a plasma membrane G protein-coupled receptor that senses small changes in circulating calcium concentration. The encoded protein couples this information to intracellular signaling pathways that modify parathyroid hormone secretion or renal cation handling, and thus this protein plays an essential role in maintaining mineral ion homeostasis. Mutations in this gene are a cause of familial hypocalciuric hypercalcemia, neonatal severe hyperparathyroidism, and autosomal dominant hypocalcemia.
• Source: HEK293
• Species: Human
• Tag: C-His
• Form: Disulfide-linked homodimer
• Bio-activity: Bioassay data are not available.
• Molecular Mass: Predicted Molecular Mass: 66 kDa
  SDS-PAGE: 90-110 kDa, reducing conditions
• Protein Length: Tyr20-Lys601
• N-terminal Sequence Analysis: Tyr20
• Endotoxin: < 1.0 EU/μg of the protein by the LAL method.
• Purity: >90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  12 months from date of receipt, -20 to -70 centigrade as supplied.
  1 month, 2 to 8 centigrade under sterile conditions after reconstitution.
  3 months, -20 to -70 centigrade under sterile conditions after reconstitution.
• Storage Buffer: Lyophilized from a 0.2 μm filtered solution in PBS.
• Reconstitution: Reconstitute at 250 μg/mL in PBS.
• Shipping: The product is shipped at ambient temperature.

Gene Information

• Gene Name: CASR calcium sensing receptor [ Homo sapiens (human) ]
• Official Symbol: CASR
• Synonyms: CASR; calcium sensing receptor; CAR; FHH; FIH; HHC; EIG8; HHC1; NSHPT; PCAR1; hCasR; GPRC2A; HYPOC1; extracellular calcium-sensing receptor; parathyroid Ca(2+)-sensing receptor 1; parathyroid cell calcium-sensing receptor 1
• Gene ID: 846
• mRNA Refseq: NM_000388
• Protein Refseq: NP_000379
• MIM: 601199
• UniProt ID: P41180