Recombinant Human CASR Protein (Y20-S1078 end), N-HA/Flag and C-10×His-tagged

• Cat.No.: CASR-23H
• Product Overview: Recombinant human HA(signal peptide)-Flag-TEV-CaSR(Y20-S1078 end)-10His was expressed in insect cells.

Specification

• Species: Human
• Source: Insect Cells
• Tag: Flag&HA&His
• Protein Length: Y20-S1078 end
• Description: The protein encoded by this gene is a plasma membrane G protein-coupled receptor that senses small changes in circulating calcium concentration. The encoded protein couples this information to intracellular signaling pathways that modify parathyroid hormone secretion or renal cation handling, and thus this protein plays an essential role in maintaining mineral ion homeostasis. Mutations in this gene are a cause of familial hypocalciuric hypercalcemia, neonatal severe hyperparathyroidism, and autosomal dominant hypocalcemia.
• Form: Liquid
• Endotoxin: < 0.01 EU/μg of the protein
• Purity: 80%
• Stability: Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade
• Storage: Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Storage Buffer: 20 mM HEPES pH 7.5, 150 mM NaCl, 0.005% GDN, 0.0005% CHS
• Shipping: It is shipped out with blue ice.

Gene Information

• Gene Name: CASR calcium-sensing receptor [ Homo sapiens (human) ]
• Official Symbol: CASR
• Synonyms: CASR; calcium-sensing receptor; HHC, HHC1, hypocalciuric hypercalcemia 1; extracellular calcium-sensing receptor; FHH; GPRC2A; NSHPT; severe neonatal hyperparathyroidism; parathyroid Ca(2+)-sensing receptor 1; parathyroid cell calcium-sensing receptor; CAR; FIH; HHC; EIG8; HHC1; PCAR1; MGC138441
• Gene ID: 846
• mRNA Refseq: NM_000388
• Protein Refseq: NP_000379
• MIM: 601199
• UniProt ID: P41180