"CBL" Related Products

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Recombinant Human CBL Protein, MYC/DDK-tagged

Cat.No. : CBL-2727H
Product Overview : Recombinant Human CBL protein, fused to MYC/DDK-tagged at C-terminus, was expressed in HEK293.
Description : This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia, and expansion of CGG repeats in the 5' UTR has been associated with Jacobsen syndrome. Mutations in this gene are also the cause of Noonan syndrome-like disorder.
Source : HEK293
Species : Human
Tag : MYC/DDK
Form : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Mass : 99.5 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration : >50 ug/mL as determined by microplate BCA method
Gene Name : CBL Cbl proto-oncogene, E3 ubiquitin protein ligase [ Homo sapiens ]
Official Symbol : CBL
Synonyms : C-CBL; CBL2; FRA11B; NSLL; RNF55
Gene ID : 867
mRNA Refseq : NM_005188
Protein Refseq : NP_005179
MIM : 165360
UniProt ID : P22681

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