| Description : |
The protein encoded by this gene is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, and is exclusively expressed in monocytes and macrophages. It functions as an acute phase-regulated receptor involved in the clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages, and may thereby protect tissues from free hemoglobin-mediated oxidative damage. This protein may also function as an innate immune sensor for bacteria and inducer of local inflammation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
125.4 kDa |
| AA Sequence : |
MSKLRMVLLEDSGSADFRRHFVNLS PFTITVVLLLSACFVTSSLGGTDKE LRLVDGENKCSGRVEVKVQEEWGTV CNNGWSMEAVSVICNQLGCPTAIKA PGWANSSAGSGRIWMDHVSCRGNES ALWDCKHDGWGKHSNCTHQQDAGVT CSDGSNLEMRLTRGGNMCSGRIEIK FQGRWGTVCDDNFNIDHASVICRQL ECGSAVSFSGSSNFGEGSGPIWFDD LICNGNESALWNCKHQGWGKHNCDH AEDAGVICSKGADLSLRLVDGVTEC SGRLEVRFQGEWGTICDDGWDSYDA AVACKQLGCPTAVTAIGRVNASKGF GHIWLDSVSCQGHEPAVWQCKHHEW GKHYCNHNEDAGVTCSDGSDLELRL RGGGSRCAGTVEVEIQRLLGKVCDR GWGLKEADVVCRQLGCGSALKTSYQ VYSKIQATNTWLFLSSCNGNETSLW DCKNWQWGGLTCDHYEEAKITCSAH REPRLVGGDIPCSGRVEVKHGDTWG SICDSDFSLEAASVLCRELQCGTVV SILGGAHFGEGNGQIWAEEFQCEGH ESHLSLCPVAPRPEGTCSHSRDVGV VCSRYTEIRLVNGKTPCEGRVELKT LGAWGSLCNSHWDIEDAHVLCQQLK CGVALSTPGGARFGKGNGQIWRHMF HCTGTEQHMGDCPVTALGASLCPSE QVASVICSGNQSQTLSSCNSSSLGP TRPTIPEESAVACIESGQLRLVNGG GRCAGRVEIYHEGSWGTICDDSWDL SDAHVVCRQLGCGEAINATGSAHFG EGTGPIWLDEMKCNGKESRIWQCHS HGWGQQNCRHKEDAGVICSEFMSLR LTSEASREACAGRLEVFYNGAWGTV GKSSMSETTVGVVCRQLGCADKGKI NPASLDKAMSIPMWVDNVQCPKGPD TLWQCPSSPWEKRLASPSEETWITC DNKIRLQEGPTSCSGRVEIWHGGSW GTVCDDSWDLDDAQVVCQQLGCGPA LKAFKEAEFGQGTGPIWLNEVKCKG NESSLWDCPARRWGHSECGHKEDAA VNCTDISVQKTPQKATTGRSSRQSS FIAVGILGVVLLAIFVALFFLTKKR RQRQRLAVSSRGENLVHQIQYREMN SCLNADDLDLMNSSENSHESADFSA AELISVSKFLPISGMEKEAILSHTE KENGNLSGPTRTRPLEQKLISEEDL AANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
