Description : |
This gene encodes a glycosyl-phosphatidylinositol (GPI)-linked cell surface glycoprotein that plays a role in neutrophil activation. The protein can bind platelet endothelial cell adhesion molecule-1 and function in neutrophil transmigration. Mutations in this gene are associated with myeloproliferative diseases. Over-expression of this gene has been found in patients with polycythemia rubra vera. Autoantibodies against the protein may result in pulmonary transfusion reactions, and it may be involved in Wegener's granulomatosis. A related pseudogene, which is adjacent to this gene on chromosome 19, has been identified. |
Source : |
HEK293 |
Species : |
Human |
Tag : |
His |
Form : |
Lyophilized |
Molecular Mass : |
42 kDa |
Protein Length : |
437 |
AA Sequence : |
MSAVLLLALLGFILPLPGVQALLCQ FGTVQHVWKVSDLPRQWTPKNTSCD SGLGCQDTLMLIESGPQVSLVLSKG CTEAKDQEPRVTEHRMGPGLSLISY TFVCRQEDFCNNLVNSLPLWAPQPP ADPGSLRCPVCLSMEGCLEGTTEEI CPKGTTHCYDGLLRLRGGGIFSNLR VQGCMPQPGCNLLNGTQEIGPVGMT ENCNRKDFLTCHRGTTIMTHGNLAQ EPTDWTTSNTEMCEVGQVCQETLLL LDVGLTSTLVGTKGCSTVGAQNSQK TTIHSAPPGVLVASYTHFCSSDLCN SASSSSVLLNSLPPQAAPVPGDRQC PTCVQPLGTCSSGSPRMTCPRGATH CYDGYIHLSGGGLSTKMSIQGCVAQ PSSFLLNHTRQIGIFSAREKRDVQP PASQHEGGGAEGLESLTWGVGLALA PALWWGVVCPSC |
Purity : |
> 98% |
Applications : |
WB; ELISA; FACS; FC |
Stability : |
This bioreagent is stable at 4 centigrade (short-term) and -70 centigrade(long-term). After reconstitution, sample may be stored at 4 centigrade for 2-7 days and below -18 centigrade for future use. |
Storage : |
At -20 centigrade. |
Concentration : |
1 mg/mL |
Storage Buffer : |
PBS (pH 7.4-7.5). Sterile-filtered colorless solution. |
Reconstitution : |
Reconstitute in sterile distilled H2O to no less than 100 μg/mL; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance. |