| Description : |
The CD1 multigene family encodes five forms of the CD1 T-cell surface glycoprotein in human, designated CD1A, 1B, 1C, 1D and 1E. CD1, a type 1 membrane protein, has structural similarity to the MHC class I antigen and has been shown to present lipid antigens for recognition by T lymphocytes. CD1 antigens are associated with β-2-Microglobulin and expressed on cortical thymocytes, Langerhans cells, a B cell subset and some dendritic cells. Specifically, CD1A is a marker for Langerhans cell histiocytosis (LCH) and is found on interdigitating cells. Adaptor-protein complexes and CD1-associated chaperones control CD1 trafficking, and the development and activation of CD1-restricted T cells. Constitutive endocytosis of CD1B molecules and the differential sorting of MHC class II from lysosomes separate peptide- and lipid antigen-presenting molecules during dendritic cell maturation. CD1B is also expressed in interdigitating cells. The human CD1 genes are all closely linked in a cluster mapping at chromosome 1q23.1. |
| Source : |
E. coli |
| Species : |
Human |
| Tag : |
C-His |
| Molecular Mass : |
~31 kDa |
| AA Sequence : |
NADASQEHVSFHVIQIFSFVNQSWA RGQGSGWLDELQTHGWDSESGTIIF LHNWSKGNFSNEELSDLELLFRFYL FGLTREIQDHASQDYSKYPFEVQVK AGCELHSGKSPEGFFQVAFNGLDLL SFQNTTWVPSPGCGSLAQSVCHLLN HQYEGVTETVYNLIRSTCPRFLLGL LDAGKMYVHRQVRPEAWLSSRPSLG SGQLLLVCHASGFYPKPVWVTWMRN EQEQLGTKHGDILPNADGTWYLQVI LEVASEEPAGLSCRVRHSSLGGQDI ILYWGHHFSM |
| Purity : |
Transferred into competent cells and the supernatant was purified by NI column affinity chromatography and the purity is > 85% (by SDS-PAGE). |
| Notes : |
For research use only, not for use in diagnostic procedure. |
| Storage : |
Store at 4 centigrade short term. Aliquot and store at -20 centigrade long term. Avoid freeze-thaw cycles. |
| Concentration : |
≥0.5 mg/mL |
| Storage Buffer : |
PBS, 4M Urea, pH7.4 |
