"CD22" Related Products

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Recombinant Human CD22 Protein, His-tagged

Cat.No. : CD22-3947H
Product Overview : Recombinant human CD22 protein (176-687aa) was expressed in HEK293 cells with His tag at C terminal.
Description : B-cell receptor CD22 is also known as Sialic acid-binding Ig-like lectin 2 (Siglec-2), B-lymphocyte cell adhesion molecule (BL-CAM), T-cell surface antigen Leu-14, which belongs to the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family. CD22 mediates B-cell B-cell interactions, and may be involved in the localization of B-cells in lymphoid tissues. Siglec-2 / CD22 binds sialylated glycoproteins, one of which is CD45. Siglec2 / CD22 plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.
Source : HEK293
Species : Human
Tag : His
Form : Lyophilized from 0.22 μm filtered solution in PBS, pH7.4.
Bio-activity : Immobilized Human CD22 Protein, His-tagged at 2 μg/mL (100 μL/well) can bind Anti-Human CD22 MAb, Human IgG1 with a linear range of 0.1-2 ng/mL (QC tested).
Molecular Mass : The protein has a calculated MW of 57.8 kDa. The protein migrates as 90-100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin : Less than 1.0 EU per μg by the LAL method.
Purity : >95% as determined by SDS-PAGE.
Storage : For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower
Gene Name : CD22 CD22 molecule [ Homo sapiens ]
Official Symbol : CD22
Synonyms : CD22; CD22 molecule; CD22 antigen; B-cell receptor CD22; sialic acid binding Ig like lectin 2; SIGLEC 2; SIGLEC2; BL-CAM; T-cell surface antigen Leu-14; B-lymphocyte cell adhesion molecule; sialic acid binding Ig-like lectin 2; sialic acid-binding Ig-like lectin 2; SIGLEC-2; FLJ22814; MGC130020
Gene ID : 933
mRNA Refseq : NM_001185099
Protein Refseq : NP_001172028
MIM : 107266
UniProt ID : P20273

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