Active Recombinant Human CD226 protein, Fc/Avi-tagged,
Cat.No. : | CD226-052H |
Product Overview : | Recombinant Human CD226(Glu19-Asn247) protein, fused to Fc/Avi tag at the C-terminus, was expressed in CHO cells . |
- Specification
- Gene Information
- Related Products
Description : | DNAX accessory molecule-1 (DNAM-1), also known as CD226, is a 65 kDa type I transmembrane glycoprotein in the immunoglobulin superfamily (1). Mature human DNAM-1 contains a 236 amino acid (aa) extracellular domain (ECD) with two Ig-like C2-set domains and a 61 aa cytoplasmic region that contains motifs for binding PDZ domains and band 4.1 family proteins (1, 2). Within the ECD, human DNAM-1 shares 50% and 52% aa sequence identity with mouse and rat DNAM-1, respectively. DNAM-1 is expressed on multiple lymphoid and myeloid cells and interacts with CD155/PVR and Nectin-2/CD112 (3, 4). Ligation of DNAM-1 promotes the activation of NK cells, CD8+ T cells, and mast cells (2-6), dendritic cell maturation, megakaryocyte and activated platelet adhesion to vascular endothelial cells, and monocyte extravasation; it inhibits the forrmation of osteoclasts (7-10). Platelet-endothelium interactions mediated by DNAM-1 enable the metastasis of tumor cells to the lung (11). In activated, but not in resting NK, T, and mast cells, the cis association of DNAM-1 with CD18 contributes to the tyrosine and serine phosphorylation of DNAM-1 during activation (6, 9, 12-14). |
Source : | CHO cells |
Species : | Human |
Tag : | Fc/Avi |
Predicted N Terminal : | Glu19 |
Form : | Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. |
Bio-activity : | Measured by its binding ability in a functional ELISA. When Recombinant Human PVR Fc Chimera is immobilized at 2 μg/mL (100 μL/well), the concentration of Recombinant Human CD226 Fc Chimera Avi-tag that produces 50% of the optimal binding response is 0.07‑0.42 μg/mL |
Molecular Mass : | 83-95 kDa |
Protein length : | Glu19-Asn247 |
Endotoxin : | <0.10 EU per 1 μg of the protein by the LAL method. |
Purity : | >95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining. |
Applications : | Bioactivity |
Storage : | Use a manual defrost freezer and avoid repeated freeze-thaw cycles.12 months from date of receipt, -20 to -70 °C as supplied.1 month, 2 to 8 °C under sterile conditions after reconstitution.3 months, -20 to -70 °C under sterile conditions after reconstitution. |
Reconstitution : | Reconstitute at 500 μg/mL in PBS. |
Gene Name : | CD226 CD226 molecule [ Homo sapiens ] |
Official Symbol : | CD226 |
Synonyms : | CD226; CD226 molecule; CD226 antigen; DNAM 1; DNAM1; PTA1; TLiSA1; adhesion glycoprotein; DNAX accessory molecule 1; DNAX accessory molecule-1; platelet and T cell activation antigen 1; T lineage-specific activation antigen 1 antigen; DNAM-1; |
Gene ID : | 10666 |
mRNA Refseq : | NM_006566 |
Protein Refseq : | NP_006557 |
MIM : | 605397 |
UniProt ID : | Q15762 |
Products Types
◆ Recombinant Protein | ||
CD226-395H | Recombinant Human CD226 Protein (Met1-Asn247), His-Fc-tagged, Biotinylated | +Inquiry |
CD226-4374H | Recombinant Human CD226 Protein, His (Fc)-Avi-tagged | +Inquiry |
CD226-220H | Recombinant Human CD226 Protein, C-His-tagged | +Inquiry |
CD226-659H | Recombinant Human CD226 Protein, Fc-tagged | +Inquiry |
Cd226-2056M | Recombinant Mouse Cd226 Protein, Myc/DDK-tagged | +Inquiry |
◆ Lysates | ||
CD226-1173RCL | Recombinant Rat CD226 cell lysate | +Inquiry |
CD226-1167CCL | Recombinant Cynomolgus CD226 cell lysate | +Inquiry |
CD226-2800MCL | Recombinant Mouse CD226 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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