Recombinant Human CD274 Protein, His-tagged
Cat.No. : | CD274-054H |
Product Overview : | Recombinant Human CD274 Protein with His tag was expressed in E. coli. |
- Specification
- Gene Information
- Related Products
Description : | Programmed cell death 1 ligand 1 (PD-L1, B7-H1, CD274) is a member of the B7 family of cell surface ligands that regulate T cell activation and immune responses. The PD-L1 ligand binds the PD-1 transmembrane receptor and inhibits T cell activation. PD-L1 was discovered following a search for novel B7 protein homologs and was later shown to be expressed by antigen presenting cells, activated T cells, and tissues including placenta, heart, and lung. Similar in structure to related B7 family members, PD-L1 protein contains extracellular IgV and IgC domains and a short, cytoplasmic region. Research studies demonstrate that PD-L1 is expressed in several tumor types, including melanoma, ovary, colon, lung, breast, and renal cell carcinomas. Expression of PD-L1 in cancer is associated with tumor-infiltrating lymphocytes, which mediate PD-L1 expression through the release of interferon gamma. Additional research links PD-L1 expression to cancers associated with viral infections. |
Source : | E. coli |
Species : | Human |
Tag : | His |
Molecular Mass : | ~30 kDa |
AA Sequence : | FTVTVPKDLYVVEYGSNMTIECKFP VEKQLDLAALIVYWEMEDKNIIQFV HGEEDLKVQHSSYRQRARLLKDQLS LGNAALQITDVKLQDAGVYRCMISY GGADYKRITVKVNAPYNKINQRILV VDPVTSEHELTCQAEGYPKAEVIWT SSDHQVLSGKTTTTNSKREEKLFNV TSTLRINTTTNEIFYCTFRRLDPEE NHTAELVIPELPLAHPPNER |
Purity : | Transferred into competent cells and the supernatant was purified by NI column affinity chromatography and the purity is > 85% (by SDS-PAGE). |
Notes : | For research use only, not for use in diagnostic procedure. |
Storage : | Store at 4 centigrade short term. Aliquot and store at -20 centigrade long term. Avoid freeze-thaw cycles. |
Storage Buffer : | PBS, 4M Urea, pH7.4 |
Gene Name : | CD274 CD274 molecule [ Homo sapiens (human) ] |
Official Symbol : | CD274 |
Synonyms : | CD274; CD274 molecule; CD274 antigen , PDCD1LG1, programmed cell death 1 ligand 1; programmed cell death 1 ligand 1; B7 homolog 1; B7 H; B7 H1; B7H1; PD L1; PDL1; CD274 antigen; PDCD1 ligand 1; programmed death ligand 1; B7-H; PD-L1; PDCD1L1; PDCD1LG1; MGC142294; MGC142296; |
Gene ID : | 29126 |
mRNA Refseq : | NM_014143 |
Protein Refseq : | NP_054862 |
MIM : | 605402 |
UniProt ID : | Q9NZQ7 |
Products Types
◆ Recombinant Protein | ||
Cd274-11M | Recombinant Mouse Cd274 Protein, His (Fc)-Avi-tagged | +Inquiry |
CD274-1081H | Recombinant Human CD274 protein(Met1-Thr239), His-tagged, Biotinylated | +Inquiry |
CD274-4367R | Recombinant Rabbit CD274 Protein | +Inquiry |
CD274-714M | Recombinant Mouse CD274 Protein, IgG2a Fc-tagged | +Inquiry |
CD274-4375H | Recombinant Human CD274 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
CD274-2642MCL | Recombinant Mouse CD274 cell lysate | +Inquiry |
CD274-2735HCL | Recombinant Human CD274 cell lysate | +Inquiry |
CD274-002RCL | Recombinant Rat CD274 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
0
Inquiry Basket