Recombinant Human CD276 Protein, C-His-tagged
Cat.No. : | CD276-145H |
Product Overview : | Recombinant Human CD276 Protein with C-His tag was expressed in E. coli. |
- Specification
- Gene Information
- Related Products
Description : | B7 homolog 3 (B7-H3, CD276) is a member of the B7 family of cell surface ligands that regulate T cell activation and immune responses. B7-H3 protein contains two extracellular Ig-like V-type domains and two IgG-like C2-type domains, a transmembrane domain, and a short intracellular domain. Early research examining the biological process of B7-H3 suggested that B7-H3 is a positive regulator of T cell response. Subsequent research studies indicated that B7-H3 is a negative regulator of T cell response, and that the protein inhibits T cell proliferation. One possibility is that B7-H3 interacts with two distinct sets of receptors, resulting in seemingly opposite biological outcomes. B7-H3 is expressed by antigen presenting cells, activated T cells, and a few normal tissues, including placenta and prostate. Expression of B7-H3 is seen in several cancer types, including prostate, breast, colon, lung, and gastric cancers, and in endothelial cells from tumor associated vasculature. |
Source : | E. coli |
Species : | Human |
Tag : | C-His |
Molecular Mass : | ~48 kDa |
AA Sequence : | LEVQVPEDPVVALVGTDATLCCSFS PEPGFSLAQLNLIWQLTDTKQLVHS FAEGQDQGSAYANRTALFPDLLAQG NASLRLQRVRVADEGSFTCFVSIRD FGSAAVSLQVAAPYSKPSMTLEPNK DLRPGDTVTITCSSYQGYPEAEVFW QDGQGVPLTGNVTTSQMANEQGLFD VHSILRVVLGANGTYSCLVRNPVLQ QDAHSSVTITPQRSPTGAVEVQVPE DPVVALVGTDATLRCSFSPEPGFSL AQLNLIWQLTDTKQLVHS FTEGRDQGSAYANRTALFPDLLAQGNASLRLQ RVRVADEGSFTCFVSIRD FGSAAVSLQVAAPYSKPSMTLEPNK DLRPGDTVTITCSSYRGYPEAEVFWQDGQGVP LTGNVTTSQMANEQGLFD VHSVLRVVLGANGTYSCLVRNPVLQQDAHGSV TITGQPMTFPPEA |
Purity : | Transferred into competent cells and the supernatant was purified by NI column affinity chromatography and the purity is > 85% (by SDS-PAGE). |
Notes : | For research use only, not for use in diagnostic procedure. |
Storage : | Store at 4 centigrade short term. Aliquot and store at -20 centigrade long term. Avoid freeze-thaw cycles. |
Concentration : | ≥0.5 mg/mL |
Storage Buffer : | PBS, 4M Urea, pH7.4 |
Gene Name : | CD276 CD276 molecule [ Homo sapiens (human) ] |
Official Symbol : | CD276 |
Synonyms : | CD276; CD276 molecule; CD276 antigen; B7 H3; B7H3; B7RP 2; B7 homolog 3; costimulatory molecule; B7-H3; B7RP-2; 4Ig-B7-H3; |
Gene ID : | 80381 |
mRNA Refseq : | NM_001024736 |
Protein Refseq : | NP_001019907 |
MIM : | 605715 |
UniProt ID : | Q5ZPR3 |
Products Types
◆ Recombinant Protein | ||
CD276-0766H | Recombinant Human CD276 Protein, His-Flag-StrepII-Tagged | +Inquiry |
CD276-1363H | Recombinant Human CD276 protein(Met1-Thr461), hFc-tagged, Biotinylated | +Inquiry |
CD276-3054H | Recombinant Human CD276 Protein, MYC/DDK-tagged | +Inquiry |
CD276-600H | Recombinant Human CD276 Protein, Fc-tagged | +Inquiry |
CD276-502H | Recombinant Human CD276 Protein (ECD) (Met1-Thr461), HIgG1 Fc-tagged, Biotinylated | +Inquiry |
◆ Lysates | ||
CD276-826RCL | Recombinant Rat CD276 cell lysate | +Inquiry |
CD276-1959HCL | Recombinant Human CD276 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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