"CD40" Related Products

Recombinant Human CD40 Protein (Met1-Arg193), His-tagged, Biotinylated

Cat.No.: CD40-1087H
Product Overview: Recombinant Human CD40 Protein (NP_001241.1) (Met1-Arg193) was produced by HEK293 Cells expression system. This protein was expressed with a polyhistidine tag at the C-terminus. The purified protein was biotinylated in vitro.
Description: CD40, also known as TNFRSF5, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins. CD40 protein plays an essential role in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. CD40 protein is expressed in B cells, dendritic cells, macrophages, endothelial cells, and several tumor cell lines. Defects in CD40 result in hyper-IgM immunodeficiency type 3 (HIGM3). In addition, CD40/CD40L interaction is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis.
Source: HEK293
Species: Human
Tag : His
Predicted N Terminal: Glu 21
Form: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Molecular Mass: The recombinant human CD40 consists of 184 amino acids and predicts a molecular mass of 20.7 kDa.
Protein length: Met1-Arg193
Endotoxin: < 1.0 EU per μg protein as determined by the LAL method.
Purity: > 95 % as determined by SDS-PAGE
Stability: Samples are stable for up to twelve months from date of receipt at -70 centigrade.
Storage: Store it under sterile conditions at -20 centigrade to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 mg/ml. Centrifuge the vial at 4ºC before opening to recover the entire contents.
Shipping: In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Gene Name: CD40 CD40 molecule, TNF receptor superfamily member 5 [ Homo sapiens ]
Official Symbol: CD40
Synonyms: CD40; Bp50; p50; CD40L receptor; CD40 type II isoform; TNFRSF5; MGC9013;
Gene ID: 958
mRNA Refseq: NM_001250
Protein Refseq: NP_001241
MIM: 109535
UniProt ID: P25942

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