Recombinant Human CD47, Fc tagged
Cat.No. : | CD47-7889H |
Product Overview : | Recombinant Human CD47 (NP_942088.1) (Met1-Pro139), fused with the Fc region of human IgG1 at the C-terminus, was produced in Human Cells. |
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Species : | Human |
Source : | Human Cells |
Tag : | Non |
Protein Length : | 1-139 a.a. |
Predicted N Terminal : | Gln 19 |
Form : | Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. |
Molecular Mass : | The recombinant human CD47/Fc is a disulfide-linked homodimer. The reduced monomer comprises 362 amino acids and has a predicted molecular mass of 40.7 kDa. The apparent molecular mass of the protein is approximately 48-60 kDa in SDS-PAGE under reducing c |
Endotoxin : | < 1.0 eu per μg of the protein as determined by the LAL method. |
Purity : | >95 % as determined by SDS-PAGE |
Stability : | Samples are stable for up to twelve months from date of receipt at -70oC. |
Storage : | Store it under sterile conditions at -20oC~-70oC. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution. Centrifuge the vial at 4℃ before opening to recover the entire contents. |
Publications : |
Co-coating of receptor-targeted drug nanocarriers with anti-phagocytic moieties enhances specific tissue uptake versus non-specific phagocytic clearance (2017)
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Gene Name | CD47 CD47 molecule [ Homo sapiens ] |
Official Symbol | CD47 |
Gene ID | 961 |
mRNA Refseq | NM_001777 |
Protein Refseq | NP_001768 |
MIM | 601028 |
UniProt ID | Q08722 |
Chromosome Location | 3q13.1-q13.2 |
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Co-coating of receptor-targeted drug nanocarriers with anti-phagocytic moieties enhances specific tissue uptake versus non-specific phagocytic clearance
Journal: Biomaterials PubMed ID: 28923682 Data: 2018/12/1
Authors: Joshua Kim, Saraudeep Sinha, Silvia Muro
Article Snippet:Monoclonal antibodies recognizing human or murine intercellular adhesion molecule 1 (ICAM-1), a cell-surface receptor overexpressed in many diseases, 35 were from hybridomas from American Type Culture Collection (Manassas, VA).Monoclonal antibodies recognizing human or murine intercellular adhesion molecule 1 (ICAM-1), a cell-surface receptor overexpressed in many diseases, 35 were from hybridomas from American Type Culture Collection (Manassas, VA).. Recombinant human or murine CD47, tagged with poly-histidine or human Fc, were from LD Biopharma Inc. (San Diego, CA) and Creative BioMart (Shirley, NY), respectively.. Antibodies to thrombospondin-1 (TSP-1) and integrin α v β 3 were from ThermoFisher Scientific (Waltham, MA) and R&D systems (Minneapolis, MN) respectively.Antibodies to thrombospondin-1 (TSP-1) and integrin α v β 3 were from ThermoFisher Scientific (Waltham, MA) and R&D systems (Minneapolis, MN) respectively.
Not For Human Consumption!
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