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CD47

Official Full Name

CD47 molecule
Overview

alphaVbeta3 is a type of integrin that is a receptor for vitronectin. It consists of two components, integrin alpha V and integrin beta 3 (CD61), and is expressed by platelets. Furthermore it is a receptor for phagocytosis on macrophages or dendritic cells. Inhibitors like etaracizumab may be used as antiangiogenics.
Synonyms

CD47; CD47 molecule; CD47 antigen (Rh related antigen, integrin associated signal transducer), MER6; leukocyte surface antigen CD47; antigen identified by monoclonal 1D8; antigenic surface determinant protein OA3; CD47 glycoprotein; IAP; integrin associated protein; OA3; Rh related antigen; Rh-related antigen; integrin-associated protein; integrin-associated signal transducer; CD47 antigen (Rh-related antigen, integrin-associated signal transducer); MER6;

Type

Recombinant Proteins
GMP Proteins
Cell & Tissue Lysates
Chromatography Reagents
Protein Pre-coupled Magnetic Beads
Assay Kits

Species

Bos taurus (Bovine)
Bovine
Canine
Chicken
Cynomolgus
Cynomolgus / Rhesus macaque
Cynomolgus monkey
Cynomolgus/Rhesus macaque
Human
Mouse
Mus musculus (Mouse)
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Rabbit
Rat
Rattus norvegicus (Rat)
Rhesus Macaque
Sus scrofa (Pig)

Source

CHO cells
E.coli
E.coli expression system
HEK293
Human Cell
Human cells
Human Cells
In Vitro Cell Free System
Insect Cell
Mammalian Cell
Mammalian cells
Mammalian Cells
Protein Conjugation
Sf9 Insect Cell
Wheat Germ

Tag

Fc
Avi
Biotin
Flag
GST
His
StrepII
mFc
T7
LEVLFQ
lIgG2b
mIgG2a
Non
rFc

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	CD47-7890H	Active Recombinant Human CD47 protein, Fc/Avi-tagged, Biotinylated	HEK293	Fc&Avi&Biotin	Gln 19 - Pro 139	Inquiry
Human	CD47-7891H	Active Recombinant Human CD47 Protein, His-tagged, Biotinylated	HEK293	His	Gln 19 - Pro 139	Inquiry
Human	CD47-5495H	Active Recombinant Human CD47 Full Length Transmembrane protein(Nanodisc)	HEK293	Non		Inquiry
Human	CD47-556H	Active Recombinant Human CD47 protein, His-Avi-tagged, Biotinylated	HEK293	His&Avi	Gln19-Pro139	$798 / 25µg
Human	CD47-051H	Active Recombinant Human CD47 protein, Fc/Avi-tagged,	CHO cells	Fc&Avi	Gln19-Pro139	Inquiry
Human	CD47-101HG	Active GMP Recombinant Human CD47 protein	HEK293		DNA sequence encoding Human CD47(NCBI Reference Sequence: NP_942088.1) was expressed with His tag at the C-terminal.	Inquiry
Human	CD47-2332H	Recombinant Human CD47 protein(Met1-Pro139), hFc-tagged	HEK293	Fc	Met1-Pro139	Inquiry
Human	CD47-7862H	Recombinant Human CD47 protein(Gln19-Pro139), His-tagged	HEK293	His	Gln19-Pro139	$786 / 50µg
Human	CD47-7889H	Recombinant Human CD47, Fc tagged	Human Cell	Non		Inquiry
Human	CD47-40H	Recombinant Human CD47 protein, hIgG-His-tagged	Insect Cell	His&Fc		Inquiry
Human	CD47-7865H	Recombinant Human CD47 protein(Met1-Pro139)	HEK293	Non	Met1-Pro139	$498 / 100µg
Human	CD47-71H	Recombinant Human CD47 protein, His-tagged	Insect Cell	His		Inquiry
Human	CD47-835H	Recombinant Human CD47 Protein, DDK/His-tagged	HEK293	His&Flag		Inquiry
Human	CD47-834H	Recombinant Human CD47 Protein, Fc-tagged	HEK293	Fc		Inquiry
Human	CD47-90H	Recombinant Human CD47 protein, T7/His-tagged	E.coli	His&T7		Inquiry
Human	CD47-333H	Recombinant CD47 protein, His/Avi-tagged	HEK293	His&Avi	121	Inquiry
Human	CD47-836H	Recombinant Human CD47 Protein, DDK-tagged	Sf9 Insect Cell	Flag		Inquiry
Human	CD47-0825H	Recombinant Human CD47 Protein	Wheat Germ	Non		Inquiry
Human	CD47-837H	Recombinant Human CD47 Protein, Fc-tagged	HEK293	Fc		Inquiry
Human	CD47-0826H	Recombinant Human CD47 Protein, His-Flag-StrepII-Tagged	Human Cell	His&Flag&StrepII		Inquiry
Human	CD47-0827H	Recombinant Human CD47 Protein, GST-Tagged	Wheat Germ	GST		Inquiry
Human	CD47-850HCL	Recombinant Human CD47 cell lysate	Human Cell	Non		Inquiry
Human	CD47-7889HAF488	Recombinant Human CD47 Protein, Fc-tagged, Alexa Fluor 488 conjugated	HEK293	Fc	362	$798 / 20μg $1,298 / 50μg $1,998 / 100μg
Human	CD47-14H	Active Recombinant Human CD47 Protein, hIgG/His-tagged	Insect Cell	His&Fc	19-141	$198 / 10μg
Human	CD47-7865HB	Recombinant Human CD47 protein, LEVLFQ-tagged, Biotinylated	HEK293	LEVLFQ		Inquiry
Human	CD47-152H	Recombinant Human CD47 Protein, DYKDDDDK-tagged	Human Cells	Flag		Inquiry
Human	CD47-3292H	Recombinant Human CD47 protein, His-tagged, low endotoxin	HEK293	His	Gln19-Pro139	$898 / 50µg
Human	CD47-7865HAF555	Recombinant Human CD47 Protein, Alexa Fluor 555 conjugated	HEK293	LEVLFQ	Met1-Pro139, 128	$798 / 20μg $1,298 / 50μg $1,998 / 100μg
Human	CD47-151H	Recombinant Human CD47 Protein, DYKDDDDK-tagged	Human cells	Flag		Inquiry
Human	CD47-7865HAF488	Recombinant Human CD47 Protein, Alexa Fluor 488 conjugated	HEK293	LEVLFQ	Met1-Pro139, 128	$798 / 20μg $1,298 / 50μg $1,998 / 100μg
Human	CD47-527H	Recombinant Human CD47 protein, Fc-tagged (HPLC-verified)	HEK293	Fc	Gln19-Pro139	Inquiry
Human	CD47-7889HAF555	Recombinant Human CD47 Protein, Fc-tagged, Alexa Fluor 555 conjugated	HEK293	Fc	362	$798 / 20μg $1,298 / 50μg $1,998 / 100μg
Human	CD47-33H	Recombinant Human CD47 Protein (ECD), Fc-His-tagged(C-ter)	HEK293	His&Fc	Gln19-Pro139	Inquiry
Human	CD47-640H	Recombinant Human CD47 Protein, Fc-tagged	HEK293	Fc	323	Inquiry
Human	CD47-555H	Recombinant Human CD47 Protein (Met1-Pro139), His-tagged	Insect Cell	His	Met1-Pro139	Inquiry
Human	CD47-7865HAF647	Recombinant Human CD47 Protein, Alexa Fluor 647 conjugated	HEK293	LEVLFQ	Met1-Pro139, 128	$798 / 20μg $1,298 / 50μg $1,998 / 100μg
Human	CD47-347H	Active Recombinant Human CD47 Protein, LIgG2b Fc-tagged, low endotoxin	HEK293	lIgG2b	Gln 19 - Pro 139	$798 / 100µg
Human	CD47-1276H	Recombinant Human CD47 Protein (Met1-Glu141), C-His tagged	Mammalian cells	His	Met1-Glu141	Inquiry
Human	CD47-2153H	Recombinant Human CD47 Protein, His-tagged	E.coli	His	Ala18-Glu141	Inquiry
Human	CD47-7889HAF647	Recombinant Human CD47 Protein, Fc-tagged, Alexa Fluor 647 conjugated	HEK293	Fc	362	$798 / 20μg $1,298 / 50μg $1,998 / 100μg
Human	CD47-348H	Recombinant Human CD47 protein, Mouse IgG2a Fc-tagged, low endotoxin	HEK293	mIgG2a	121	Inquiry
Human	CD47-508H	Recombinant Human CD47 Protein (Gln19-Gln141, Val198-Ala207, Ser257-Gly268), C-mFc and 6×His-tagged	HEK293	His&mFc	Gln19-Gln141, Val198-Ala207, Ser257-Gly268	Inquiry
Human	CD47-2784H	Recombinant Human CD47 Protein, His-tagged, OVA Conjugated	Protein Conjugation	His	Glu308-Glu323	Inquiry
Human	CD47-199H	Recombinant Human CD47 Protein, C-His-tagged	E.coli	His		Inquiry
Human	CD47-2186H	Active Recombinant Human CD47 protein, His-tagged	HEK293	His	Met1-Pro139	Inquiry
Human	CD47-0252H	Recombinant Human CD47 protein, Biotinylated	HEK293	Non	Met1-Pro139	Inquiry
Human	CD47-2993HF	Recombinant Full Length Human CD47 Protein	In Vitro Cell Free System		99 amino acids	Inquiry
Human	CD47-1239H	Recombinant Human CD47 Protein (Gln19-Pro139), N-His tagged	E.coli	His	Gln19-Pro139	Inquiry
Human	CD47-987M	PE-labeled CD47 protein-coupled magnetic Beads				Inquiry
Human	CD47-7865HF	Recombinant Human CD47 Protein, FITC conjugated	HEK293	LEVLFQ	Met1-Pro139, 128	$798 / 20μg $1,298 / 50μg $1,998 / 100μg
Human	CD47-2996HF	Recombinant Full Length Human CD47 Protein, GST-tagged	In Vitro Cell Free System	GST	323 amino acids	Inquiry
Human	CD47-7889HF	Recombinant Human CD47 Protein, Fc-tagged, FITC conjugated	HEK293	Fc	362	$798 / 20μg $1,298 / 50μg $1,998 / 100μg
Human	CD47-641H	Recombinant Human CD47 Protein, IgG2a Fc-tagged	HEK293	Fc	323	Inquiry
Human	CD47-645H	Recombinant Human CD47 Protein, His and Avi-tagged	HEK293	His&Avi	323	Inquiry
Human	CD47-639H	Recombinant Human CD47 Protein	HEK293		323	Inquiry
Human	CD47-0989M	Active CD47 protein-coupled magnetic Beads	HEK293		Gln 19 - Pro 139	Inquiry
Mouse	Cd47-645M	Active Recombinant Mouse Cd47 protein, Fc-tagged	Mammalian cells	Fc	Gln19-Pro158	Inquiry
Mouse	Cd47-647MF	Recombinant Mouse Cd47 Protein, His-tagged, FITC conjugated	HEK293	His	Met1-Lys140, 133	$798 / 20μg $1,298 / 50μg $1,998 / 100μg
Mouse	CD47-3095M	Recombinant Mouse Cd47 protein, Fc-tagged	HEK293	Fc	Gln19-Pro158	$461 / 50µg
Mouse	Cd47-647M	Recombinant Mouse Cd47 protein, His-tagged	HEK293	His	Met1-Lys140	Inquiry
Mouse	Cd47-5727M	Recombinant Mouse Cd47 protein, His-tagged	E.coli	His	Ala18~Gly219	Inquiry
Mouse	CD47-3094M	Recombinant Mouse Cd47 protein, His-tagged	HEK293	His	Gln19-Pro158	Inquiry
Mouse	Cd47-646M	Recombinant Mouse Cd47 protein, Fc-tagged	HEK293	Fc	122	Inquiry
Mouse	Cd47-18M-B	Recombinant Mouse Cd47 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	CD47-382M	Active Recombinant Mouse CD47 protein, His-tagged	HEK293	His	Gln19-Lys140	$786 / 100µg
Mouse	CD47-892M	Recombinant Mouse CD47 Protein (Met1-Lys140), RlgG Fc-tagged	HEK293	rFc	Met1-Lys140	$461 / 50µg
Mouse	CD47-384M	Recombinant Mouse CD47 protein, Mouse IgG2a Fc-tagged, low endotoxin	HEK293	mIgG2a	122	Inquiry
Mouse	Cd47-647MAF647	Recombinant Mouse Cd47 Protein, His-tagged, Alexa Fluor 647 conjugated	HEK293	His	Met1-Lys140, 133	$798 / 20μg $1,298 / 50μg $1,998 / 100μg
Mouse	CD47-0248M	Recombinant Mouse CD47 protein, Fc -tagged	HEK293	Fc	Met1-Lys140	Inquiry
Mouse	CD47-380M	Recombinant Mouse CD47 protein (Met1-Lys140)	HEK293			$498 / 50µg
Mouse	Cd47-5707M	Recombinant Mouse Cd47 Protein (Met1-Ile162), C-His tagged	Mammalian cells	His	Met1-Ile162	Inquiry
Mouse	Cd47-647MAF555	Recombinant Mouse Cd47 Protein, His-tagged, Alexa Fluor 555 conjugated	HEK293	His	Met1-Lys140, 133	$798 / 20μg $1,298 / 50μg $1,998 / 100μg
Mouse	CD47 -0245M	Recombinant Mouse CD47 protein	HEK293	Non	Met1-Lys140	Inquiry
Mouse	Cd47-647MAF488	Recombinant Mouse Cd47 Protein, His-tagged, Alexa Fluor 488 conjugated	HEK293	His	Met1-Lys140, 133	$798 / 20μg $1,298 / 50μg $1,998 / 100μg
Mouse	Cd47-18M	Recombinant Mouse Cd47 Protein, His (Fc)-Avi-tagged	HEK293	His&Fc&Avi		Inquiry
Mouse	CD47-642M	Recombinant Mouse CD47 Protein, Fc-tagged	HEK293	Fc	303	Inquiry
Rat	CD47-1255R	Recombinant Rat CD47 Protein	Mammalian Cell	His		Inquiry
Rat	Cd47-7480R	Recombinant Rat Cd47 protein, Fc-tagged	HEK293	Fc	Gln19-Lys140	$786 / 100µg
Rat	Cd47-8767R	Active Recombinant Rat Cd47, His tagged	HEK293	His	Met1-Lys140	$498 / 50µg
Rat	CD47-1363RCL	Recombinant Rat CD47 cell lysate	Human Cell	Non		Inquiry
Rat	CD47-913R	Recombinant Rat CD47 Protein, His (Fc)-Avi-tagged	HEK293	His&Fc&Avi		Inquiry
Rat	Cd47-8767RF	Recombinant Rat Cd47 Protein, His-tagged, FITC conjugated	HEK293	His	133	$798 / 20μg $1,298 / 50μg $1,998 / 100μg
Rat	Cd47-8767RAF488	Recombinant Rat Cd47 Protein, His-tagged, Alexa Fluor 488 conjugated	HEK293	His	133	$798 / 20μg $1,298 / 50μg $1,998 / 100μg
Rat	Cd47-7480RAF555	Recombinant Rat Cd47 Protein, hFc-tagged, Alexa Fluor 555 conjugated	HEK293	Fc	Gln19-Lys140	$798 / 20μg $1,298 / 50μg $1,998 / 100μg
Rat	Cd47-7480RAF488	Recombinant Rat Cd47 Protein, hFc-tagged, Alexa Fluor 488 conjugated	HEK293	Fc	Gln19-Lys140	$798 / 20μg $1,298 / 50μg $1,998 / 100μg
Rat	Cd47-8767RAF555	Recombinant Rat Cd47 Protein, His-tagged, Alexa Fluor 555 conjugated	HEK293	His	133	$798 / 20μg $1,298 / 50μg $1,998 / 100μg
Rat	Cd47-7480RAF647	Recombinant Rat Cd47 Protein, hFc-tagged, Alexa Fluor 647 conjugated	HEK293	Fc	Gln19-Lys140	$798 / 20μg $1,298 / 50μg $1,998 / 100μg
Rat	Cd47-8767RAF647	Recombinant Rat Cd47 Protein, His-tagged, Alexa Fluor 647 conjugated	HEK293	His	133	$798 / 20μg $1,298 / 50μg $1,998 / 100μg
Rat	CD47-913R-B	Recombinant Rat CD47 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rat	Cd47-7480RF	Recombinant Rat Cd47 Protein, hFc-tagged, FITC conjugated	HEK293	Fc	Gln19-Lys140	$798 / 20μg $1,298 / 50μg $1,998 / 100μg
Rat	CD47-644R	Recombinant Rat CD47 Protein, Fc-tagged	HEK293	Fc	303	Inquiry
Rabbit	Cd47-70R	Recombinant Rabbit Cd47 protein, Fc-tagged	HEK293	Fc	Gln19-Glu139	Inquiry
Rabbit	CD47-643R	Recombinant Rabbit CD47 Protein, Fc-tagged	HEK293	Fc	321	Inquiry
Bos taurus (Bovine)	RFL25841BF	Recombinant Full Length Bovine Leukocyte Surface Antigen Cd47(Cd47) Protein, His-Tagged	E.coli expression system	His	Full Length of Mature Protein (19-303)	Inquiry
Bovine	CD47-112B	Recombinant Bovine CD47 Protein, His-tagged	Mammalian Cells	His	Gln19 - Asn140	Inquiry
Bovine	CD47-1B-B	Recombinant Bovine CD47 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Bovine	CD47-113B	Recombinant Bovine CD48 Protein, Fc-tagged	Mammalian Cells	Fc	Gln19 - Asn140	Inquiry
Bovine	CD47-1B	Recombinant Bovine CD47 Protein, His (Fc)-Avi-tagged	HEK293	His&Fc&Avi		Inquiry
Canine	CD47-862C	Recombinant Canine CD47 protein, His-tagged	HEK293	His	Gln19-Asn140	Inquiry
Cynomolgus	CD47-1017C	Recombinant Cynomolgus CD47 Protein (Met1-Asn142), HlgG1 Fc-tagged	HEK293	Fc	Met1-Asn142	Inquiry
Cynomolgus / Rhesus macaque	CD47-1946C	Active Recombinant Cynomolgus / Rhesus macaque CD47 protein, Fc-tagged	HEK293	Fc	Gln 19 - Glu 141	Inquiry
Cynomolgus / Rhesus macaque	CD47-679C	Active Recombinant Cynomolgus / Rhesus macaque CD47 protein, His-tagged	HEK293	His	Gln 19 - Glu 141	Inquiry
Cynomolgus monkey	CD47-638C	Recombinant Cynomolgus monkey CD47 Protein, Fc-tagged	HEK293	Fc	307	Inquiry
Cynomolgus/Rhesus macaque	CD47-745C	Recombinant Cynomolgus/Rhesus macaque CD47 protein, Fc-tagged	HEK293	Fc	Gln4-Glu126	Inquiry
Cynomolgus/Rhesus macaque	CD47-346C	Recombinant Cynomolgus/Rhesus macaque CD47 protein, His-tagged	HEK293	His	123	Inquiry
Cynomolgus/Rhesus macaque	CD47-674C	Recombinant Cynomolgus/Rhesus macaque CD47 protein, His-tagged	HEK293	His	Met1-Asn142	Inquiry
Mus musculus (Mouse)	RFL14932MF	Recombinant Full Length Mouse Leukocyte Surface Antigen Cd47(Cd47) Protein, His-Tagged	E.coli expression system	His	Full Length of Mature Protein (19-303)	Inquiry
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)	RFL31430PF	Recombinant Full Length Pongo Abelii Leukocyte Surface Antigen Cd47(Cd47) Protein, His-Tagged	E.coli expression system	His	Full Length of Mature Protein (19-323)	Inquiry
Rattus norvegicus (Rat)	RFL27649RF	Recombinant Full Length Rat Leukocyte Surface Antigen Cd47(Cd47) Protein, His-Tagged	E.coli expression system	His	Full Length of Mature Protein (19-303)	Inquiry
Rhesus Macaque	CD47-743R	Recombinant Rhesus monkey CD47 Protein, His-tagged	Mammalian Cell	His		Inquiry
Rhesus Macaque	CD47-745R	Recombinant Rhesus Macaque CD47(Gln19-Glu141) Protein, N-6*His-Flag-tagged	HEK293	His&Flag		Inquiry
Rhesus Macaque	CD47-569R-B	Recombinant Rhesus Macaque CD47 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rhesus Macaque	CD47-569R	Recombinant Rhesus Macaque CD47 Protein, His (Fc)-Avi-tagged	HEK293	His&Fc&Avi		Inquiry
Sus scrofa (Pig)	RFL17555SF	Recombinant Full Length Pig Leukocyte Surface Antigen Cd47(Cd47) Protein, His-Tagged	E.coli expression system	His	Full Length of Mature Protein (19-303)	Inquiry
Chicken	CD47-1207C	Recombinant Chicken CD47	Mammalian Cell	His		Inquiry
	Kit-1706	CD47:SIRP-α[Biotinylated] Inhibitor Screening Assay Kit		Non		Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource

CD47 involved in several pathways and played different roles in them. We selected most pathways CD47 participated on our site, such as ECM-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with CD47 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
ECM-receptor interaction	ITGB8;THBS4;LAMA4;COL4A6;VTN;CD44;SV2C;LAMB1;LAMA2

CD47 has several biochemical functions, for example, protein binding, thrombospondin receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CD47 itself. We selected most functions CD47 had, and list some proteins which have the same functions with CD47. You can find most of the proteins on our site.

Function	Related Protein
protein binding	BPTF;FBXL3;CST7;FCGR2B;STX3;BMF;ABCF1;NCOA1;USH1C
thrombospondin receptor activity	CD47;F2;SDC4

CD47 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CD47 here. Most of them are supplied by our site. Hope this information will be useful for your research of CD47.

SYNE4; SIRPG; b3xyc5_sollc

Research Area

Cancer Drug Targets

Immune Checkpoints

Immunoglobulin Superfamily CAMs

Immune Regulatory Molecules on Endothelial Cells

Dendritic Cell Pathogen Recognition/Uptake

Bladder Cancer Stem Cell Markers

Leukemia Cancer Stem Cell Markers

Banerjee, R; Khandelwal, S; et al. CD47 regulates the phagocytic clearance and replication of the Plasmodium yoelii malaria parasite. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 112:3062-3067(2015).

Feng, MY; Chen, JY; et al. Macrophages eat cancer cells using their own calreticulin as a guide: Roles of TLR and Btk. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 112:2145-2150(2015).