Recombinant Human CD9 Protein, C-His-tagged
Cat.No. : | CD9-178H |
Product Overview : | Recombinant Human CD9 Protein with C-His tag was expressed in E. coli. |
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Description : | The CD9 antigen belongs to the tetraspanin family of cell surface glycoproteins, and is characterized by four transmembrane domains, one short extracellular domain (ECL1), and one long extracellular domain (ECL2). Tetraspanins interact with a variety of cell surface proteins and intracellular signaling molecules in specialized tetraspanin-enriched microdomains (TEMs), where they mediate a range of processes including adhesion, motility, membrane organization, and signal transduction. Research studies demonstrate that CD9 expression on the egg is required for gamete fusion during fertilization. CD9 was also shown to play a role in dendritic cell migration, megakaryocyte differentiation, and homing of cord blood CD34+ hematopoietic progenitors to the bone marrow. In addition, down regulation of CD9 expression is associated with poor prognosis and progression of several types of cancer. Additional research identified CD9 as an abundant component of exosomes, and may play some role in the fusion of these secreted membrane vesicles with recipient cells. |
Source : | E. coli |
Species : | Human |
Tag : | His |
Molecular Mass : | ~9 kDa |
AA Sequence : | SHKDEVIKEVQEFYKDTYNKLKTKD EPQRETLKAIHYALNCCGLAGGVEQ FISDICPKKDVLETFTVKSCPDAIK EVFDNKFHI |
Purity : | Transferred into competent cells and the supernatant was purified by NI column affinity chromatography and the purity is > 85% (by SDS-PAGE). |
Notes : | For research use only, not for use in diagnostic procedure. |
Storage : | Store at 4 centigrade short term. Aliquot and store at -20 centigrade long term. Avoid freeze-thaw cycles. |
Concentration : | ≥0.5 mg/mL |
Storage Buffer : | PBS, 4M Urea, pH7.4 |
Gene Name : | CD9 CD9 molecule [ Homo sapiens (human) ] |
Official Symbol : | CD9 |
Synonyms : | CD9; CD9 molecule; CD9 antigen (p24) , MIC3; CD9 antigen; BA2; motility related protein 1; MRP 1; P24; TSPAN29; 5H9 antigen; tetraspanin-29; BA-2/p24 antigen; CD9 antigen (p24); leukocyte antigen MIC3; motility related protein-1; cell growth-inhibiting gene 2 protein; MIC3; MRP-1; BTCC-1; DRAP-27; TSPAN-29; FLJ99568; |
Gene ID : | 928 |
mRNA Refseq : | NM_001769 |
Protein Refseq : | NP_001760 |
MIM : | 143030 |
UniProt ID : | P21926 |
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◆ Lysates | ||
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Not For Human Consumption!
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Customer Reviews (3)
Write a reviewIts unique characteristics contribute to obtaining clear and detailed structural information, allowing researchers to gain insights into protein interactions and conformational changes.
The CD9 protein comes highly recommended for its exceptional performance in various research applications.
Its exceptional purity and stability make it an ideal choice for a wide range of applications, ensuring reliable and reproducible results.
Q&As (5)
Ask a questionStudies have suggested that CD9 protein expression levels may be associated with chemoresistance in certain types of cancer, making it a potential predictive marker for chemotherapy response.
Studies have suggested that changes in CD9 protein expression in renal cells may be associated with the progression of chronic kidney disease, making it a potential biomarker for monitoring disease progression.
As of now, there are no FDA-approved diagnostic tests or therapies specifically targeting CD9 protein, but ongoing research may lead to future applications.
CD9 protein expression has been associated with cardiovascular diseases such as atherosclerosis and thrombosis, and its levels are being studied as a potential prognostic marker for these conditions.
CD9 protein is involved in the regulation of mast cell activation and degranulation, processes that are central to the development of asthma and allergic reactions.
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