| Description : |
This gene encodes a member of the p34Cdc2 protein kinase family. p34Cdc2 kinase family members are known to be essential for eukaryotic cell cycle control. This gene is in close proximity to CDC2L1, a nearly identical gene in the same chromosomal region. The gene loci including this gene, CDC2L1, as well as metalloprotease MMP21/22, consist of two identical, tandemly linked genomic regions, which are thought to be a part of the larger region that has been duplicated. This gene and CDC2L1 were shown to be deleted or altered frequently in neuroblastoma with amplified MYCN genes. The protein kinase encoded by this gene could be cleaved by caspases and was demonstrated to play roles in cell apoptosis. Many transcript variants encoding several different isoforms have been found for this gene, but the full-length nature of only two have been determined so far. |
| Conjugation : |
HIS |
| Source : |
E. coli |
| Tissue specificity : |
Expressed ubiquitously. Some evidence of isoform-specific tissue distribution. |
| Form : |
Lyophilised:Reconstitution with 117 μl aqua dest. |
| Storage buffer : |
Preservative: NoneConstituents: 0.5% Trehalose, 6M Urea, 100mM Sodium phosphate, 10mM Sodium chloride, pH 4.5 |
| Storage : |
Shipped at 4°C. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles. |
| Sequences of amino acids : |
NENHLLVVPESRFDRDSGESEEAEE EVGEGTPQSSALTEG DYVPDSPALLPIELKQELPKYLPAL QGCRSVEEFQCLN RIEEGTYGVVYRAKDKKTDEIVALK RLKMEKEKEGFPI TSLREINTILKAQHPNIVTVREIVV GSNMDKIYIVMNYVE HDLKSLMETMKQPFLPGEVKTLMIQ LLRGVKHLHDNWI LHRDLKTSNLLLSHAGILKVGDFGL AREYGSPLKAYTP VVVTQWYRAPELLLGAKEYSTAVDM WSVGCIFGELLTQKPLFPGNSEIDQ INKVF |
| Sequence Similarities : |
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.Contains 1 protein kinase domain. |
