Recombinant Human CEACAM3 Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: CEACAM3-2314H
• Product Overview: CEACAM3 MS Standard C13 and N15-labeled recombinant protein (NP_001806) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: This gene encodes a member of the family of carcinoembryonic antigen-related cell adhesion molecules (CEACAMs), which are used by several bacterial pathogens to bind and invade host cells. The encoded transmembrane protein directs phagocytosis of several bacterial species that is dependent on the small GTPase Rac. It is thought to serve an important role in controlling human-specific pathogens by the innate immune system. Alternatively spliced transcript variants have been described.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 27.1 kDa
• AA Sequence: MGPPSASPHRECIPWQGLLLTASLL NFWNPPTTAKLTIESMPLSVAEGKE VLLLVHNLPQHLFGYSWYKGERVDG NSLIVGYVIGTQQATPGAAYSGRET IYTNASLLIQNVTQNDIGFYTLQVI KSDLVNEEATGQFHVYQENAPGLPV GAVAGIVTGVLVGVALVAALVCFLL LAKTGRTSIQRDLKEQQPQALAPGR GPSHSSAFSMSPLSTAQAPLPNPRT AASIYEELLKHDTNIYCRMDHKAEV ASTRTRPLEQKLISEEDLAANDILD YKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: CEACAM3 carcinoembryonic antigen-related cell adhesion molecule 3 [ Homo sapiens (human) ]
• Official Symbol: CEACAM3
• Synonyms: CEACAM3; carcinoembryonic antigen-related cell adhesion molecule 3; CGM1; CD66d; CD66d antigen; carcinoembryonic antigen CGM1; nonspecific cross-reacting antigen; carcinoembryonic antigen gene family member 1; CEA; W264; W282; CD66D; MGC119875
• Gene ID: 1084
• mRNA Refseq: NM_001815
• Protein Refseq: NP_001806
• MIM: 609142
• UniProt ID: P40198

Reviews

02/25/2022

Reliable data source, a dependable research ally.

12/22/2020

Top-notch analysis, vital for research outcomes.

11/18/2019

Expertise shines, an integral part of our research.

Q&As

How does CEACAM3 contribute to pathogen recognition?

It identifies pathogens by binding to their surfaces, aiding immune recognition.

What is the primary role of CEACAM3 in immune defense?

CEACAM3 is crucial for recognizing and responding to bacterial pathogens.

How does CEACAM3 interact with other immune receptors?

CEACAM3 works with immune receptors to coordinate bacterial defense.

How do genetic variations in CEACAM3 affect immune responses?

Genetic variations in CEACAM3 affect pathogen recognition and immune efficiency.

What is the impact of altered CEACAM3 activity on bacterial infections?

Altered CEACAM3 activity influences the body's ability to fight bacterial infections.

What role does CEACAM3 play in phagocytosis?

CEACAM3 is key in phagocytosis, helping to engulf and eliminate bacteria.

What potential therapeutic applications arise from targeting CEACAM3 in infectious diseases?

Targeting CEACAM3 could enhance immune responses against bacterial infections.