Recombinant Human Cell Division Cycle 26 Homolog (S. cerevisiae), His-tagged

• Cat.No.: CDC26-1678H
• Product Overview: Recombinant humanCDC26 protein, fused to His-tag at N-terminus, was expressed in E. coli andpurified by using conventional chromatography.

Specification

• Species: Human
• Source: Human
• Tag: His
• Description: CDC26, also known asANAPC12, APC12, belongs to the CDC26 family which orchestrates progressionthrough mitosis by decorating cell-cycle regulators with ubiquitin chains.This protein is component of the anaphase promoting complex/cyclosome(APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progressionthrough mitosis and the G1 phase of the cell cycle. The APC/C complex acts bymediating ubiquitination and subsequent degradation of target proteins.
• Concentration: 1 mg/ml
• Form: Suppliedas a liquid in 20 mM Tris-HCl buffer, pH 8.0, containing 40% glycerol and 0.1M NaCl.
• Purity: > 90% by SDS-PAGE
• Sequence: 1-85 amino acids:MGSSHHHHHH SSGLVPRGSH MLRRKPTRLE LKLDDIEEFE NIRKDLETRK KQKEDVEVVG GSDGEGAIGLSSDPKSREQM INDRIGYKPQ PKPNNRSSQF GSLEF
• Molecular Mass: 11.9 kDa (105 aa),confirmed by MALDI-TOF.
• Applications: SDS-PAGE
• Storage: Store at 4 deg C forshort term storage (1/2 weeks). Aliquot and store at -20 deg C or -70 deg Cfor long term storage. Avoid repeated freeze/thaw cycles.
• OfficialSymbol: CDC26

Gene Information

• Gene Name: CDC26 cell division cycle 26homolog (S. cerevisiae) [ Homo sapiens ]
• Synonyms: CDC26; cell divisioncycle 26 homolog (S. cerevisiae); APC12; ANAPC12; C9orf17; anaphase-promotingcomplex subunit CDC26; OTTHUMP00000021952; anaphase promoting complex subunit12; anaphase-promoting complex subunit 12; cell division cycle protein 26homolog; CDC26 subunit of anaphase promoting complex; cell division cycle 26;chromosome 9 open reading frame 17; Anaphase-promoting complex subunit 12
• Gene ID: 246184
• mRNA Refseq: NM_139286
• Protein Refseq: NP_644815
• UniProt ID: Q8NHZ8
• Chromosome Location: 9q32
• Pathway: APC/C complex;APC/C-mediated degradation of cell cycle proteins; APC/C: Cdc20 mediateddegradation of Cyclin B; APC/C: Cdc20 mediated degradation of Securin; APC/C:Cdc20 mediated degradation of mitotic proteins; APC/C: Cdh1 mediateddegradation of Cdc20 and other APC/C: Cdh1 targeted proteins in latemitosis/early G1; Activation of APC/C and APC/C: Cdc20 mediated degradationof mitotic proteins; Adaptive Immunity Signaling; Cell Cycle, Mitotic; Cellcycle; HTLV-I infection; Immune System; Inhibition of the proteolyticactivity of APC/C required for the onset of anaphase by mitotic spindlecheckpoint components; Oocyte meiosis; Phosphorylation of the APC/C;Regulation of APC/C activators between G1/S and early anaphase