Recombinant Human CFHR5 Protein, GST-tagged

• Cat.No.: CFHR5-5191H
• Product Overview: Human CFHR5 full-length ORF ( NP_110414.1, 1 a.a. - 569 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene is a member of a small complement factor H (CFH) gene cluster on chromosome 1. Each member of this gene family contains multiple short consensus repeats (SCRs) typical of regulators of complement activation. The protein encoded by this gene has nine SCRs with the first two repeats having heparin binding properties, a region within repeats 5-7 having heparin binding and C reactive protein binding properties, and the C-terminal repeats being similar to a complement component 3 b (C3b) binding domain. This protein co-localizes with C3, binds C3b in a dose-dependent manner, and is recruited to tissues damaged by C-reactive protein. Allelic variations in this gene have been associated, but not causally linked, with two different forms of kidney disease: membranoproliferative glomerulonephritis type II (MPGNII) and hemolytic uraemic syndrome (HUS). [provided by RefSeq, Jan 2010]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 90.8 kDa
• AA Sequence: MLLLFSVILISWVSTVGGEGTLCDF PKIHHGFLYDEEDYNPFSQVPTGEV FYYSCEYNFVSPSKSFWTRITCTEE GWSPTPKCLRMCSFPFVKNGHSESS GLIHLEGDTVQIICNTGYSLQNNEK NISCVERGWSTPPICSFTKGECHVP ILEANVDAQPKKESYKVGDVLKFSC RKNLIRVGSDSVQCYQFGWSPNFPT CKGQVRSCGPPPQLSNGEVKEIRKE EYGHNEVVEYDCNPNFIINGPKKIQ CVDGEWTTLPTCVEQVKTCGYIPEL EYGYVQPSVPPYQHGVSVEVNCRNE YAMIGNNMITCINGIWTELPMCVAT HQLKRCKIAGVNIKTLLKLSGKEFN HNSRIRYRCSDIFRYRHSVCINGKW NPEVDCTEKREQFCPPPPQIPNAQN MTTTVNYQDGEKVAVLCKENYLLPE AKEIVCKDGRWQSLPRCVESTAYCG PPPSINNGDTTSFPLSVYPPGSTVT YRCQSFYKLQGSVTVTCRNKQWSEP PRCLDPCVVSEENMNKNNIQLKWRN DGKLYAKTGDAVEFQCKFPHKAMIS SPPFRAICQEGKFEYPICE
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: CFHR5 complement factor H related 5 [ Homo sapiens (human) ]
• Official Symbol: CFHR5
• Synonyms: CFHR5; complement factor H related 5; FHR5; CFHL5; FHR-5; CFHR5D; complement factor H-related protein 5; factor H-related protein 5
• Gene ID: 81494
• mRNA Refseq: NM_030787
• Protein Refseq: NP_110414
• MIM: 608593
• UniProt ID: Q9BXR6