Recombinant Human CHMP2B Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: CHMP2B-5021H
• Product Overview: CHMP2B MS Standard C13 and N15-labeled recombinant protein (NP_054762) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: This gene encodes a component of the heteromeric ESCRT-III complex (Endosomal Sorting Complex Required for Transport III) that functions in the recycling or degradation of cell surface receptors. ESCRT-III functions in the concentration and invagination of ubiquitinated endosomal cargos into intralumenal vesicles. The protein encoded by this gene is found as a monomer in the cytosol or as an oligomer in ESCRT-III complexes on endosomal membranes. It is expressed in neurons of all major regions of the brain. Mutations in this gene result in one form of familial frontotemporal lobar degeneration.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 23.7 kDa
• AA Sequence: MASLFKKKTVDDVIKEQNRELRGTQ RAIIRDRAALEKQEKQLELEIKKMA KIGNKEACKVLAKQLVHLRKQKTRT FAVSSKVTSMSTQTKVMNSQMKMAG AMSTTAKTMQAVNKKMDPQKTLQTM QNFQKENMKMEMTEEMINDTLDDIF DGSDDEEESQDIVNQVLDEIGIEIS GKMAKAPSAARSLPSASTSKATISD EEIERQLKALGVDTRTRPLEQKLIS EEDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: CHMP2B charged multivesicular body protein 2B [ Homo sapiens (human) ]
• Official Symbol: CHMP2B
• Synonyms: CHMP2B; charged multivesicular body protein 2B; chromatin modifying protein 2B; charged multivesicular body protein 2b; CHMP2.5; DKFZP564O123; VPS2 homolog B (S. cerevisiae); VPS2B; VPS2 homolog B; vacuolar protein-sorting-associated protein 2-2; DMT1; VPS2-2; DKFZp564O123
• Gene ID: 25978
• mRNA Refseq: NM_014043
• Protein Refseq: NP_054762
• MIM: 609512
• UniProt ID: Q9UQN3