Recombinant Human CLCF1 Protein, Myc/DDK-tagged, C13 and N15-labeled
Cat.No. : | CLCF1-5167H |
Product Overview : | CLCF1 MS Standard C13 and N15-labeled recombinant protein (NP_037378) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells. |
- Specification
- Gene Information
- Related Products
Description : | This gene is a member of the glycoprotein (gp)130 cytokine family and encodes cardiotrophin-like cytokine factor 1 (CLCF1). CLCF1 forms a heterodimer complex with cytokine receptor-like factor 1 (CRLF1). This dimer competes with ciliary neurotrophic factor (CNTF) for binding to the ciliary neurotrophic factor receptor (CNTFR) complex, and activates the Jak-STAT signaling cascade. CLCF1 can be actively secreted from cells by forming a complex with soluble type I CRLF1 or soluble CNTFR. CLCF1 is a potent neurotrophic factor, B-cell stimulatory agent and neuroendocrine modulator of pituitary corticotroph function. Defects in CLCF1 cause cold-induced sweating syndrome 2 (CISS2). This syndrome is characterized by a profuse sweating after exposure to cold as well as congenital physical abnormalities of the head and spine. Alternative splicing results in multiple transcript variants encoding distinct isoforms. |
Source : | HEK293 |
Species : | Human |
Tag : | Myc/DDK |
Molecular Mass : | 25.2 kDa |
AA Sequence : | MDLRAGDSWGMLACLCTVLWHLPAV PALNRTGDPGPGPSIQKTYDLTRYL EHQLRSLAGTYLNYLGPPFNEPDFN PPRLGAETLPRATVDLEVWRSLNDK LRLTQNYEAYSHLLCYLRGLNRQAA TAELRRSLAHFCTSLQGLLGSIAGV MAALGYPLPQPLPGTEPTWTPGPAH SDFLQKMDDFWLLKELQTWLWRSAK DFNRLKKKMQPPAAAVTLHLGAHGF TRTRPLEQKLISEEDLAANDILDYK DDDDKV |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 3 months from receipt of products under proper storage and handling conditions. |
Storage : | Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
Concentration : | 50 μg/mL as determined by BCA |
Storage Buffer : | 100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
Gene Name : | CLCF1 cardiotrophin-like cytokine factor 1 [ Homo sapiens (human) ] |
Official Symbol : | CLCF1 |
Synonyms : | CLCF1; cardiotrophin-like cytokine factor 1; CRLF1 associated cytokine like factor 1; B cell stimulating factor 3; BSF 3; BSF3; CISS2; CLC; cold induced sweating syndrome 2; NNT 1; NNT1; novel neurotrophin 1; NR6; novel neurotrophin-1; B-cell stimulating factor 3; B-cell stimulatory factor 3; B-cell-stimulating factor 3; CRLF1 associated cytokine-like factor 1; neurotrophin-1/B-cell stimulating factor-3; BSF-3; NNT-1; |
Gene ID : | 23529 |
mRNA Refseq : | NM_013246 |
Protein Refseq : | NP_037378 |
MIM : | 607672 |
UniProt ID : | Q9UBD9 |
Products Types
◆ Recombinant Protein | ||
Clcf1-2178M | Recombinant Mouse Clcf1 Protein, Myc/DDK-tagged | +Inquiry |
CLCF1-3242H | Recombinant Human CLCF1 Protein, MYC/DDK-tagged | +Inquiry |
Clcf1-619M | Recombinant Mouse Clcf1 Protein, His-tagged | +Inquiry |
CLCF1-618H | Recombinant Human CLCF1 Protein, His-tagged | +Inquiry |
CLCF1-1413H | Recombinant Human CLCF1 Protein, GST-tagged | +Inquiry |
◆ Lysates | ||
CLCF1-001HCL | Recombinant Human CLCF1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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