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Active Recombinant Human CLK4 Protein, GST-tagged

Cat.No. : CLK4-1500H
Product Overview : Human CLK4 (NP_065717.1, 1 a.a. - 481 a.a.) full-length recombinant protein with GST tag expressed in baculovirus infected Sf21 cells.
  • Specification
  • Gene Information
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Description : The protein encoded by this gene belongs to the CDC2-like protein kinase (CLK) family. This protein kinase can interact with and phosphorylate the serine- and arginine-rich (SR) proteins, which are known to play an important role in the formation of spliceosomes, and thus may be involved in the regulation of alternative splicing. Studies in the Israeli sand rat Psammomys obesus suggested that the ubiquitin-like 5 (UBL5/BEACON), a highly conserved ubiquitin-like protein, may interact with and regulate the activity of this kinase. Multiple alternatively spliced transcript variants have been observed, but the full-length natures of which have not yet been determined. [provided by RefSeq, Jul 2008]
Source : Insect Cells
Species : Human
Tag : GST
Form : Liquid
Bio-activity : The activity was determined by IMAPTM assay. The enzyme was incubated with fluorescein labeled peptide and phosphorylation was detected by IMAPTM technology (fluorescence polarization). Substrate: SRPKtide. ATP: 100 uM.
Molecular Mass : 85 kDa
Purity : 87 % by SDS-PAGE/CBB staining
Applications : Functional Study
SDS-PAGE
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : In 50 mM Tris-HCl, 150 mM NaCl, pH 7.5 (0.1% CHAPS, 1 mM DTT, 10% glycerol)
Gene Name : CLK4 CDC-like kinase 4 [ Homo sapiens ]
Official Symbol : CLK4
Synonyms : CLK4; CDC-like kinase 4; dual specificity protein kinase CLK4; protein serine threonine kinase Clk4; DKFZp686A20267;
Gene ID : 57396
mRNA Refseq : NM_020666
Protein Refseq : NP_065717
MIM : 607969
UniProt ID : Q9HAZ1

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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