Recombinant Human CLP1 Protein, GST-tagged

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Recombinant Human CLP1 Protein, GST-tagged

CLP1 Related Products

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Cat.No. : CLP1-4667H
Product Overview : Human HEAB full-length ORF ( NP_006822.1, 1 a.a. - 425 a.a.) recombinant protein with GST-tag at N-terminal.
Description : This gene encodes a member of the Clp1 family. The encoded protein is a multifunctional kinase which is a component of the tRNA splicing endonuclease complex and a component of the pre-mRNA cleavage complex II. This protein is implicated in tRNA, mRNA, and siRNA maturation. Mutations in this gene are associated with pontocerebellar hypoplasia type 10 (PCH10). Alternatively splice transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 74 kDa
AA Sequence : MGEEANDDKK PTTKFELERE TELRFEVEAS QSVQLELLTG MAEIFGTELT RNKKFTFDAG AKVAVFTWHG CSVQLSGRTE VAYVSKDTPM LLYLNTHTAL EQMRRQAEKE EERGPRVMVV GPTDVGKSTV CRLLLNYAVR LGRRPTYVEL DVGQGSVSIP GTMGALYIER PADVEEGFSI QAPLVYHFGS TTPGTNIKLY NKITSRLADV FNQRCEVNRR ASVSGCVINT CGWVKGSGYQ ALVHAASAFE VDVVVVLDQE RLYNELKRDL PHFVRTVLLP KSGGVVERSK DFRRECRDER IREYFYGFRG CFYPHAFNVK FSDVKIYKVG APTIPDSCLP LGMSQEDNQL KLVPVTPGRD MVHHLLSVST AEGTEENLSE TSVAGFIVVT SVDLEHQVFT VLSPAPRPLP KNFLLIMDIR FMDLK
Applications : Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -8 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Quality Control Testing :

12.5% SDS-PAGE Stained with Coomassie Blue.

Gene Name : CLP1 cleavage and polyadenylation factor I subunit 1 [ Homo sapiens (human) ]
Official Symbol : CLP1
Synonyms : CLP1; cleavage and polyadenylation factor I subunit 1; HEAB; hClp1; polyribonucleotide 5'-hydroxyl-kinase Clp1; ATP/GTP-binding protein; homolog of yeast CFIA subunit Clp1p; polyadenylation factor Clp1; polynucleotide kinase Clp1; pre-mRNA cleavage complex II protein Clp1; EC 2.7.1.78
Gene ID : 10978
mRNA Refseq : NM_001142597
Protein Refseq : NP_001136069
MIM : 608757
UniProt ID : Q92989

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