Recombinant Human CLP1 Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: CLP1-5007H
• Product Overview: CLP1 MS Standard C13 and N15-labeled recombinant protein (NP_006822) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: This gene encodes a member of the Clp1 family. The encoded protein is a multifunctional kinase which is a component of the tRNA splicing endonuclease complex and a component of the pre-mRNA cleavage complex II. This protein is implicated in tRNA, mRNA, and siRNA maturation. Mutations in this gene are associated with pontocerebellar hypoplasia type 10 (PCH10). Alternatively splice transcript variants encoding different isoforms have been found for this gene.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 47.6 kDa
• AA Sequence: MGEEANDDKKPTTKFELERETELRF EVEASQSVQLELLTGMAEIFGTELT RNKKFTFDAGAKVAVFTWHGCSVQL SGRTEVAYVSKDTPMLLYLNTHTAL EQMRRQAEKEEERGPRVMVVGPTDV GKSTVCRLLLNYAVRLGRRPTYVEL DVGQGSVSIPGTMGALYIERPADVE EGFSIQAPLVYHFGSTTPGTNIKLY NKITSRLADVFNQRCEVNRRASVSG CVINTCGWVKGSGYQALVHAASAFE VDVVVVLDQERLYNELKRDLPHFVR TVLLPKSGGVVERSKDFRRECRDER IREYFYGFRGCFYPHAFNVKFSDVK IYKVGAPTIPDSCLPLGMSQEDNQL KLVPVTPGRDMVHHLLSVSTAEGTE ENLSETSVAGFIVVTSVDLEHQVFT VLSPAPRPLPKNFLLIMDIRFMDLK TRTRPLEQKLISEEDLAANDILDYK DDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: CLP1 cleavage factor polyribonucleotide kinase subunit 1 [ Homo sapiens (human) ]
• Official Symbol: CLP1
• Synonyms: CLP1; cleavage factor polyribonucleotide kinase subunit 1; HEAB; hClp1; polyribonucleotide 5'-hydroxyl-kinase Clp1; ATP/GTP-binding protein; cleavage and polyadenylation factor I subunit 1; homolog of yeast CFIA subunit Clp1p; polyadenylation factor Clp1; polynucleotide kinase Clp1; pre-mRNA cleavage complex II protein Clp1; EC 2.7.1.78
• Gene ID: 10978
• mRNA Refseq: NM_006831
• Protein Refseq: NP_006822
• MIM: 608757
• UniProt ID: Q92989