Recombinant Human Colony Stimulating Factor 1 (macrophage)

• Cat.No.: CSF1-339H
• Product Overview: Recombinant human CSF1was expressed in E. coli and purified recombinant Human CSF1 protein.

Specification

• Cat. No.: CSF1-339H
• Description: CSF1 is a potenthematopoietic factor produced by a variety of cells including lymphocytes,monocytes, fibroblasts, endothelial cells, myoblasts and osteoblasts. It is akey regulator of cellular proliferation, differentiation, and survival ofblood monocytes, tissue macrophages and their progenitor cells. CSF1 has beenshown to play important roles in modulating dermal thickness, and male andfemale fertility. CSF1 is clinically used in the treatment of infection,malignancies and atherosclerosis. It facilitates hematopoietic recovery afterbone marrow transplantation.
• Source: Human
• Host: E. coli
• Form: Supplied as alyophilized powder.
• Purity: > 98% pure by SDSPAGE and HPLC
• Sequence: Region of M-CSFprotein corresponding to amino acids MEVSEHCSHM IGNGHLQILQ QLIDSQMETACLIEYKFVDQ EQLDDPVCYL KKAFVLVQVI IEETMRFKDN TPNANATERL QELSMKLNSC FIKDYKEQNEACVQTYKESP LRLLEKIKNF FNETKNFLEK DWNIFSKNCN DSLAKCSSRD VVTKP.
• Molecular Mass: 18.1 kDa
• Applications: Numerousapplications are possible with this product and should be tested by the enduser under their own laboratory conditions.
• Storage: Store at 4 deg Cuntil reconstitution. Following reconstitution aliquot and freeze at -20 degC for long term storage. Avoid repeated freeze/thaw cycles.
• OfficialSymbol: CSF1

Gene Information

• Gene Name: CSF1 colony stimulating factor 1(macrophage) [ Homo sapiens ]
• Synonyms: CSF1; colony stimulating factor1 (macrophage); MCSF; MGC31930; colony stimulating factor 1;OTTHUMP00000013363; OTTHUMP00000013364; macrophage colony stimulating factor;M-CSF; CSF-1; Lanimostim; OTTHUMP00000013362
• Gene ID: 1435
• mRNA Refseq: NM_000757
• Protein Refseq: NP_000748
• MIM: 120420
• UniProt ID: P09603
• Chromosome Location: 1p21-p13
• Pathway: Cytokine-cytokine receptorinteraction; Hematopoietic cell lineage; Osteoclastdifferentiation; Rheumatoid arthritis; Signaling events mediated by PTP1B;Signaling events mediated by TCPTP
• Function: cytokine activity; growthfactor activity; macrophage colony stimulating factor receptor binding;protein binding; protein homodimerization activity