Recombinant Human COMT Protein, His/SUMO-tagged


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Recombinant Human COMT Protein, His/SUMO-tagged

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Cat.No. : COMT-015H
Product Overview : Recombinant Human COMT protein (2-221) with a N-terminal His/SUMO-tag was expressed in E.coli
Description : Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters.
Source : E. coli
Species : Human
Tag : His/SUMO
Molecular Mass : 37.6 kDa
Protein length : 2-221
Purity : ≥70% estimated by SDS-PAGE
Unit Definition : One unit produces 1 nmol/hr of O-methylated products from 3,4-dihydroxyacetophenone (DHAP) with S-adenosyl-L-methionine (SAM) as substrate at pH 7.6, 37 centigrade, measured by absorbance at 344 nm.
Stability : ≥ 2 years
Storage : 4 centigrade
Storage Buffer : 50 mM Hepes, pH 8.0, with 500 mM NaCl and 10% glycerol
Shipping : Dry ice in continental US, may vary elsewhere.
SDS-PAGE Analysis of COMT :

Lane 1: MW Markers
Lane 2: S-COMT (4 µg)
Lane 3: S-COMT (2 µg)
Lane 4: S-COMT (1 µg)

COMT Enzyme Titration :

Gene Name : COMT catechol-O-methyltransferase [ Homo sapiens (human) ]
Official Symbol : COMT
Synonyms : COMT; catechol-O-methyltransferase; HEL-S-98n; catechol O-methyltransferase; catechol-O-methyltransferase isoform; epididymis secretory sperm binding protein Li 98n; testicular tissue protein Li 42; EC
Gene ID : 1312
mRNA Refseq : NM_000754
Protein Refseq : NP_000745
MIM : 116790
UniProt ID : P21964
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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