Recombinant Human COPS2 Protein (1-443 aa), His-tagged

• Cat.No.: COPS2-2307H
• Product Overview: Recombinant Human COPS2 Protein (1-443 aa) is produced by Yeast expression system. This protein is fused with a 6xHis tag at the N-terminal. Research Area: Signal Transduction. Protein Description: Full Length.

Specification

• Description: Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1.
• Source: Yeast
• Species: Human
• Tag: His
• Form: Tris-based buffer,50% glycerol
• Molecular Mass: 53.6 kDa
• Protein length: 1-443 aa
• AA Sequence: MSDMEDDFMCDDEEDYDLEYSEDSN SEPNVDLENQYYNSKALKEDDPKAA LSSFQKVLELEGEKGEWGFKALKQM IKINFKLTNFPEMMNRYKQLLTYIR SAVTRNYSEKSINSILDYISTSKQM DLLQEFYETTLEALKDAKNDRLWFK TNTKLGKLYLEREEYGKLQKILRQL HQSCQTDDGEDDLKKGTQLLEIYAL EIQMYTAQKNNKKLKALYEQSLHIK SAIPHPLIMGVIRECGGKMHLREGE FEKAHTDFFEAFKNYDESGSPRRTT CLKYLVLANMLMKSGINPFDSQEAK PYKNDPEILAMTNLVSAYQNNDITE FEKILKTNHSNIMDDPFIREHIEEL LRNIRTQVLIKLIKPYTRIHIPFIS KELNIDVADVESLLVQCILDNTIHG RIDQVNQLLELDHQKRGGARYTALD KWTNQLNSLNQAVVSKLA
• Purity: > 85% as determined by SDS-PAGE.
• Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
• Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
• Concentration: A hardcopy of COA will be sent along with the products. Please refer to it for detailed information.

Gene Information

• Gene Name: COPS2 COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis) [ Homo sapiens ]
• Official Symbol: COPS2
• Synonyms: COPS2; ALIEN; CSN2; TRIP15; TRIP-15; alien homolog; signalosome subunit 2; SGN2
• Gene ID: 9318
• mRNA Refseq: NM_001143887
• Protein Refseq: NP_001137359
• MIM: 604508
• UniProt ID: P61201