Recombinant Human CSE1L Over-expression Cell Lysate
Cat.No. : | CSE1L-9523HCL |
- Specification
- Gene Information
- Related Products
Description : | Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in apoptosis and in cell proliferation. Alternatively spliced transcript variants have been found for this gene. |
Source : | Human HEK293T cell line |
Species : | Human |
Tag : | C-terminal Myc/DDK |
Form : | 25mM Tris-HCl pH7.6, 150mM NaCl, 1% NP-40, 1mM EDTA, 1xProteinase inhibitor cocktail mix (Sigma), 1mM PMSF and 1mM Na3VO4 |
Molecular Mass : | 110.2 kDa |
Usage : | 1 vial of 100 µg gene specific transient over-expression cell lysate in RIPA buffer 1 vial of 100 µg empty vector transfected control cell lysate in RIPA buffer 1 vial of 250ul 2xSDS Sample Buffer (4% SDS, 125mM Tris-HCl pH6.8, 10% Glycerol, 0.002% Bromphenol blue, 100mM DTT) |
Storage : | Upon receiving, store the sample at -20 centigrade. Lysate samples are stable for 12 months from date of receipt when stored at -20 centigrade. Avoid repeated freeze-thaw cycles. Lysate samples can be diluted with 2xSDS Sample Buffer provided. After dilution, the protein sample should be aliquoted and stored at -20 centigrade for long term storage. Prior to SDS-PAGE fractionation, boil the lysate for 5 minutes. |
Gene Name : | CSE1L CSE1 chromosome segregation 1-like (yeast) [ Homo sapiens ] |
Official Symbol : | CSE1L |
Synonyms : | CSE1L; CSE1 chromosome segregation 1-like (yeast); chromosome segregation 1 (yeast homolog) like; exportin-2; CAS; CSE1; XPO2; exp2; importin-alpha re-exporter; chromosome segregation 1-like protein; cellular apoptosis susceptibility protein; MGC117283; MGC130036; MGC130037; |
Gene ID : | 1434 |
mRNA Refseq : | NM_001316 |
Protein Refseq : | NP_001307 |
MIM : | 601342 |
UniProt ID : | P55060 |
Chromosome Location : | 20q13 |
Pathway : | Direct p53 effectors, organism-specific biosystem; p53 pathway, organism-specific biosystem; |
Function : | importin-alpha export receptor activity; protein binding; protein transporter activity; |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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