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Recombinant Human CTNNB1 Protein, Myc/DDK-tagged, C13 and N15-labeled

Cat.No. : CTNNB1-1327H
Product Overview : CTNNB1 MS Standard C13 and N15-labeled recombinant protein (NP_001895) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.
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Description : The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants.
Source : HEK293
Species : Human
Tag : Myc/DDK
Molecular Mass : 85.3 kDa
AA Sequence : MATQADLMELDMAMEPDRKAAVSHW QQQSYLDSGIHSGATTTAPSLSGKG NPEEEDVDTSQVLYEWEQGFSQSFT QEQVADIDGQYAMTRAQRVRAAMFP ETLDEGMQIPSTQFDAAHPTNVQRL AEPSQMLKHAVVNLINYQDDAELAT RAIPELTKLLNDEDQVVVNKAAVMV HQLSKKEASRHAIMRSPQMVSAIVR TMQNTNDVETARCTAGTLHNLSHHR EGLLAIFKSGGIPALVKMLGSPVDS VLFYAITTLHNLLLHQEGAKMAVRL AGGLQKMVALLNKTNVKFLAITTDC LQILAYGNQESKLIILASGGPQALV NIMRTYTYEKLLWTTSRVLKVLSVC SSNKPAIVEAGGMQALGLHLTDPSQ RLVQNCLWTLRNLSDAATKQEGMEG LLGTLVQLLGSDDINVVTCAAGILS NLTCNNYKNKMMVCQVGGIEALVRT VLRAGDREDITEPAICALRHLTSRH QEAEMAQNAVRLHYGLPVVVKLLHP PSHWPLIKATVGLIRNLALCPANHA PLREQGAIPRLVQLLVRAHQDTQRR TSMGGTQQQFVEGVRMEEIVEGCTG ALHILARDVHNRIVIRGLNTIPLFV QLLYSPIENIQRVAAGVLCELAQDK EAAEAIEAEGATAPLTELLHSRNEG VATYAAAVLFRMSEDKPQDYKKRLS VELTSSLFRTEPMAWNETADLGLDI GAQGEPLGYRQDDPSYRSFHSGGYG QDALGMDPMMEHEMGGHHPGADYPV DGLPDLGHAQDLMDGLPPGDSNQLA WFDTDLTRTRPLEQKLISEEDLAAN DILDYKDDDDKV
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 3 months from receipt of products under proper storage and handling conditions.
Storage : Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
Concentration : 50 μg/mL as determined by BCA
Storage Buffer : 100 mM glycine, 25 mM Tris-HCl, pH 7.3.
Gene Name : CTNNB1 catenin beta 1 [ Homo sapiens (human) ]
Official Symbol : CTNNB1
Synonyms : CTNNB1; catenin (cadherin-associated protein), beta 1, 88kDa; catenin (cadherin associated protein), beta 1 (88kD), CTNNB; catenin beta-1; beta catenin; CTNNB; FLJ25606; FLJ37923; DKFZp686D02253;
Gene ID : 1499
mRNA Refseq : NM_001904
Protein Refseq : NP_001895
MIM : 116806
UniProt ID : P35222

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Is the CTNNB1 protein involved in the progression of pancreatic cancer? 12/20/2022

Yes, CTNNB1 is implicated in the development and progression of pancreatic cancer, with its dysregulated activity contributing to tumor growth, invasion, and metastasis.

How is the CTNNB1 protein associated with hepatocellular carcinoma (HCC)? 09/15/2022

Mutations in the CTNNB1 gene lead to the stabilization and accumulation of β-catenin, contributing to the development of HCC, making it a potential biomarker for the diagnosis and prognosis of HCC.

How is the CTNNB1 protein linked to the prognosis of gastric cancer patients? 05/08/2021

Studies have shown that CTNNB1 expression levels can serve as an independent prognostic factor in gastric cancer, with high CTNNB1 expression correlating with poor patient outcomes.

Are there any targeted therapies specifically aimed at CTNNB1 in cancer treatment? 10/10/2018

While there are no direct CTNNB1-targeted therapies available, various drugs targeting the Wnt signaling pathway are being developed and tested, which indirectly impact CTNNB1 activity in cancer cells.

How is the expression of CTNNB1 in breast cancer cells associated with patient survival? 03/12/2016

High expression levels of CTNNB1 in breast cancer cells have been linked to poor prognosis and shorter overall survival, indicating its potential as a prognostic marker for breast cancer.

Customer Reviews (3)

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03/27/2023

    Not only does it provide reliable and consistent results due to its high quality and purity, but it also holds significant value in understanding cellular processes and disease mechanisms.

    07/28/2017

      the CTNNB1 protein offers numerous advantages in trials and research experiments.

      06/24/2016

        This commitment to excellence ensures that researchers are provided with the most advanced and reliable tools for their investigations.

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