Recombinant Human CTNS Protein, GST-tagged

• Cat.No.: CTNS-2090H
• Product Overview: Human CTNS full-length ORF ( AAH32850.1, 1 a.a. - 400 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene encodes a seven-transmembrane domain protein that functions to transport cystine out of lysosomes. Its activity is driven by the H+ electrochemical gradient of the lysosomal membrane. Mutations in this gene cause cystinosis, a lysosomal storage disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2009]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 71.5 kDa
• AA Sequence: MIRNWLTIFILFPLKLVEKCESSVS LTVPPVVKLENGSSTNVSLTLRPPL NATLVITFEITFRSKNITILELPDE VVVPPGVTNSSFQVTSQNVGQLTVY LHGNHSNQTGPRIRFLVIRSSAISI INQVIGWIYFVAWSISFYPQVIMNW RRKSVIGLSFDFVALNLTGFVAYSV FNIGLLWVPYIKEQFLLKYPNGVNP VNSNDVFFSLHAVVLTLIIIVQCCL YERGGQRVSWPAIGFLVLAWLFAFV TMIVAAVGVITWLQFLFCFSYIKLA VTLVKYFPQAYMNFYYKSTEGWSIG NVLLDFTGGSFSLLQMFLQSYNNDQ WTLIFGDPTKFGLGVFSIVFDVVFF IQHFCLYRKRPGLQAARTGSGSRLR QDWAPSLQPKALPQTTSVSASSLKG
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: CTNS cystinosin, lysosomal cystine transporter [ Homo sapiens ]
• Official Symbol: CTNS
• Synonyms: CTNS; cystinosin, lysosomal cystine transporter; cystinosis, nephropathic; cystinosin; CTNS LSB; PQLC4; CTNS-LSB
• Gene ID: 1497
• mRNA Refseq: NM_001031681
• Protein Refseq: NP_001026851
• MIM: 606272
• UniProt ID: O60931