| Description : |
Core component of multiple SCF-like ECS (Elongin-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimulated by adenovirus E1B-55 kDa protein. May form a cell surface vasopressin receptor. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
91 kDa |
| AA Sequence : |
MATSNLLKNKGSLQFEDKWDFMRPI VLKLLRQESVTKQQWFDLFSDVHAV CLWDDKGPAKIHQALKEDILEFIKQ AQARVLSHQDDTALLKAYIVEWRKF FTQCDILPKPFCQLEITLMGKQGSN KKSNVEDSIVRKLMLDTWNESIFSN IKNRLQDSAMKLVHAERLGEAFDSQ LVIGVRESYVNLCSNPEDKLQIYRD NFEKAYLDSTERFYRTQAPSYLQQN GVQNYMKYADAKLKEEEKRALRYLE TRRECNSVEALMECCVNALVTSFKE TILAECQGMIKRNETEKLHLMFSLM DKVPNGIEPMLKDLEEHIISAGLAD MVAAAETITTDSEKYVEQLLTLFNR FSKLVKEAFQDDPRFLTARDKAYKA VVNDATIFKLELPLKQKGVGLKTQP ESKCPELLANYCDMLLRKTPLSKKL TSEEIEAKLKEVLLVLKYVQNKDVF MRYHKAHLTRRLILDISADSEIEEN MVEWLREVGMPADYVNKLARMFQDI KVSEDLNQAFKEMHKNNKLALPADS VNIKILNAGAWSRSSEKVFVSLPTE LEDLIPEVEEFYKKNHSGRKLHWHH LMSNGIITFKNEVGQYDLEVTTFQL AVLFAWNQRPREKISFENLKLATEL PDAELRRTLWSLVAFPKLKRQVLLY EPQVNSPKDFTEGTLFSVNQEFSLI KNAKVQKRGKINLIGRLQLTTERMR EEENEGIVQLRILRTQEAIIQIMKM RKKISNAQLQTELVEILKNMFLPQK KMIKEQIEWLIEHKYIRRDESDINT FIYMATRTRPLEQKLISEEDLAAND ILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
