Recombinant Human CX3CL1 Protein

Cat.No. : CX3CL1-482H
Product Overview : Recombinant human CX3CL1 protein
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Description : This gene belongs to the CX3C subgroup of chemokines, characterized by the number of amino acids located between the conserved cysteine residues. This is the only member of the CX3C subgroup, which contains three amino acids between cysteine residues, resulting in a Cys-X-X-X-Cys configuration. The encoded protein contains an extended mucin-like stalk with a chemokine domain on top, and exists in both a membrane-anchored form where it acts as a binding molecule, or, in soluble form, as a chemotactic cytokine. The mature form of this protein can be cleaved at the cell surface, yielding different soluble forms that can interact with the G-protein coupled receptor, C-X3-C motif chemokine receptor 1 gene product. This gene plays a role in a wide range of diseases, including cancer, vasculitis, neuropathies, atherosclerosis, inflammatory diseases, and in human immunodeficiency virus infections.
Species : Human
Form : Lyophilized
Protein length : 397
AA Sequence : MAPISLSWLLRLATFCHLTVLLAGQ HHGVTKCNITCSKMTSKIPVALLIH YQQNQASCGKRAIILETRQHRLFCA DPKEQWVKDAMQHLDRQAAALTRNG GTFEKQIGEVKPRTTPAAGGMDESV VLEPEATGESSSLEPTPSSQEAQRA LGTSPELPTGVTGSSGTRLPPTPKA QDGGPVGTELFRVPPVSTAATWQSS APHQPGPSLWAEAKTSEAPSTQDPS TQASTASSPAPEENAPSEGQRVWGQ GQSPRPENSLEREEMGPVPAHTDAF QDWGPGSMAHVSVVPVSSEGTPSRE PVASGSWTPKAEEPIHATMDPQRLG VLITPVPDAQAATRRQAVGLLAFLG LLFCLGVAMFTYQSLQGCPRKMAGE MAEGLRYIPRSCGSNSYVLVPV
Purity : > 98%
Applications : WB; ELISA; FACS; FC
Stability : This bioreagent is stable at 4 centigrade (short-term) and -70 centigrade(long-term). After reconstitution, sample may be stored at 4 centigrade for 2-7 days and below -18 centigrade for future use.
Storage : At -20 centigrade.
Storage Buffer : PBS (pH 7.4-7.5). Sterile-filtered colorless solution.
Reconstitution : Reconstitute in sterile distilled H2O to no less than 100 μg/mL; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance.
Gene Name : CX3CL1 chemokine (C-X3-C motif) ligand 1 [ Homo sapiens (human) ]
Official Symbol : CX3CL1
Synonyms : CX3CL1; chemokine (C-X3-C motif) ligand 1; SCYD1, small inducible cytokine subfamily D (Cys X3 Cys), member 1 (fractalkine, neurotactin); fractalkine; ABCD 3; C3Xkine; CXC3; CXC3C; neurotactin; NTN; C-X3-C motif chemokine 1; small-inducible cytokine D1; CX3C membrane-anchored chemokine; small inducible cytokine subfamily D (Cys-X3-Cys), member-1; small inducible cytokine subfamily D (Cys-X3-Cys), member 1 (fractalkine, neurotactin); NTT; SCYD1; ABCD-3;
Gene ID : 6376
mRNA Refseq : NM_002996
Protein Refseq : NP_002987
MIM : 601880
UniProt ID : P78423

Not For Human Consumption!

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Reviews
03/15/2022

    the CX3CL1 protein's compatibility with various experimental techniques further supports its usability.

    08/06/2021

      One of the standout features of the CX3CL1 protein is the excellent technical support provided by the manufacturer.

      06/03/2021

        Whether I need to study protein-protein interactions, protein localization, or protein folding, the CX3CL1 protein consistently delivers precise and meaningful data.

        Q&As (5)

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        In what ways is CX3CL1 linked to the modulation of pain perception and neuropathic pain conditions? 04/30/2021

        CX3CL1 is involved in pain modulation, and its dysregulation is associated with neuropathic pain conditions. Understanding its role may lead to the development of novel analgesic therapies.

        Are there any ongoing clinical trials targeting CX3CL1 for therapeutic purposes? 09/14/2020

        Yes, several clinical trials are investigating the therapeutic potential of targeting CX3CL1 in various diseases, including cancer, neurodegenerative disorders, and cardiovascular diseases.

        In cardiovascular diseases, how does CX3CL1 impact inflammation and vascular function? 03/23/2020

        CX3CL1 contributes to inflammation in cardiovascular diseases and affects vascular function. Studying its role helps in understanding the pathophysiology of conditions like atherosclerosis.

        How does CX3CL1 influence the recruitment and activation of immune cells in the context of inflammation? 01/06/2019

        CX3CL1 acts as a chemoattractant, facilitating the recruitment and activation of immune cells at the site of inflammation, playing a pivotal role in immune response regulation.

        How is CX3CL1 being investigated for its potential as a biomarker in various diseases? 05/19/2016

        Researchers are exploring CX3CL1 as a potential biomarker for diseases such as rheumatoid arthritis and certain cancers, aiming to develop diagnostic tools and monitor disease progression.

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