Recombinant Human CXXC4 Protein, GST-tagged
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Cat.No. : | CXXC4-2205H |
Product Overview : | Human CXXC4 full-length ORF ( NP_079488.1, 1 a.a. - 198 a.a.) recombinant protein with GST-tag at N-terminal. |
Description : | This gene encodes a CXXC-type zinc finger domain-containing protein that functions as an antagonist of the canonical wingless/integrated signaling pathway. The encoded protein negatively regulates wingless/integrated signaling through interaction with the post synaptic density protein/ Drosophila disc large tumor suppressor/ zonula occludens-1 protein domain of Dishevelled, a scaffolding protein required for the stabilization of the transcriptional co-activator beta-catenin. In addition, the CXXC domain of this protein has been shown to bind unmethylated CpG dinucleotides, localize to promoters and CpG islands, and interact with the catalytic domain of methylcytosine dioxygenase ten-eleven-translocation 2, an iron and alpha-ketoglutarate-dependent dioxygenase that modifies the methylation status of DNA. In humans, a mutation in this gene has been associated with development of malignant renal cell carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015] |
Source : | Wheat Germ |
Species : | Human |
Tag : | GST |
Molecular Mass : | 47.4 kDa |
AA Sequence : | MHHRNDSQRL GKAGCPPEPS LQMANTNFLS TLSPEHCRPL AGECMNKLKC GAAEAEIMNL PERVGTFSAI PALGGISLPP GVIVMTALHS PAAASAAVTD SAFQIANLAD CPQNHSSSSS SSSGGAGGAN PAKKKRKRCG VCVPCKRLIN CGVCSSCRNR KTGHQICKFR KCEELKKKPG TSLERTPVPS AEAFRWFF |
Applications : | Enzyme-linked Immunoabsorbent Assay Western Blot (Recombinant protein) Antibody Production Protein Array |
Notes : | Best use within three months from the date of receipt of this protein. |
Storage : | Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Quality Control Testing: : |
![]() 12.5% SDS-PAGE Stained with Coomassie Blue. |
Gene Name : | CXXC4 CXXC finger protein 4 [ Homo sapiens ] |
Official Symbol : | CXXC4 |
Synonyms : | CXXC4; CXXC finger protein 4; CXXC-type zinc finger protein 4; Dvl binding protein IDAX (inhibition of the Dvl and Axin complex); IDAX; CXXC finger 4; inhibition of the Dvl and axin complex protein; Dvl-binding protein IDAX (inhibition of the Dvl and Axin complex); MGC149872; |
Gene ID : | 80319 |
mRNA Refseq : | NM_025212 |
Protein Refseq : | NP_079488 |
MIM : | 611645 |
UniProt ID : | Q9H2H0 |
◆ Recombinant Protein
CXXC4-432H | Recombinant Human CXXC4 Protein, His-tagged | +Inquiry |
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◆ Lysates
CXXC4-7150HCL | Recombinant Human CXXC4 293 Cell Lysate | +Inquiry |
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