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Recombinant Human CXXC4 Protein, GST-tagged

Cat.No. : CXXC4-2205H
Product Overview : Human CXXC4 full-length ORF ( NP_079488.1, 1 a.a. - 198 a.a.) recombinant protein with GST-tag at N-terminal.
  • Specification
  • Gene Information
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Description : This gene encodes a CXXC-type zinc finger domain-containing protein that functions as an antagonist of the canonical wingless/integrated signaling pathway. The encoded protein negatively regulates wingless/integrated signaling through interaction with the post synaptic density protein/ Drosophila disc large tumor suppressor/ zonula occludens-1 protein domain of Dishevelled, a scaffolding protein required for the stabilization of the transcriptional co-activator beta-catenin. In addition, the CXXC domain of this protein has been shown to bind unmethylated CpG dinucleotides, localize to promoters and CpG islands, and interact with the catalytic domain of methylcytosine dioxygenase ten-eleven-translocation 2, an iron and alpha-ketoglutarate-dependent dioxygenase that modifies the methylation status of DNA. In humans, a mutation in this gene has been associated with development of malignant renal cell carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 47.4 kDa
AA Sequence : MHHRNDSQRLGKAGCPPEPSLQMAN TNFLSTLSPEHCRPLAGECMNKLKC GAAEAEIMNLPERVGTFSAIPALGG ISLPPGVIVMTALHSPAAASAAVTD SAFQIANLADCPQNHSSSSSSSSGG AGGANPAKKKRKRCGVCVPCKRLIN CGVCSSCRNRKTGHQICKFRKCEEL KKKPGTSLERTPVPSAEAFRWFF
Applications : Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Gene Name : CXXC4 CXXC finger protein 4 [ Homo sapiens ]
Official Symbol : CXXC4
Synonyms : CXXC4; CXXC finger protein 4; CXXC-type zinc finger protein 4; Dvl binding protein IDAX (inhibition of the Dvl and Axin complex); IDAX; CXXC finger 4; inhibition of the Dvl and axin complex protein; Dvl-binding protein IDAX (inhibition of the Dvl and Axin complex); MGC149872;
Gene ID : 80319
mRNA Refseq : NM_025212
Protein Refseq : NP_079488
MIM : 611645
UniProt ID : Q9H2H0

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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