Recombinant Human CYP17A1 Protein


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Recombinant Human CYP17A1 Protein

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Cat.No. : CYP17A1-02H
Product Overview : Recombinant human CYP17A1 and human CYP-reductase without tag was coexpressed in Escherichia coli.
Amount: 0.5 nmol cytochrome P450
Description : This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. It has both 17alpha-hydroxylase and 17,20-lyase activities and is a key enzyme in the steroidogenic pathway that produces progestins, mineralocorticoids, glucocorticoids, androgens, and estrogens. Mutations in this gene are associated with isolated steroid-17 alpha-hydroxylase deficiency, 17-alpha-hydroxylase/17,20-lyase deficiency, pseudohermaphroditism, and adrenal hyperplasia.
Source : E. coli
Species : Human
Bio-activity : Cytochrome c Reductase Activity: 25 nmol/min/mg protein
P450 Activity Data(Unless otherwise stated, all assays are carried out at 37 centigrade in 50 mM potassium phosphate buffer (pH 7.4) containing 5 mM magnesium chloride and an NADPH generating system [5 mM glucose 6-phosphate, 1 mM NADP+, 1 U/ml glucose 6-phosphate dehydrogenase])
Activity: Progesterone 17α-hydroxylase
Linear with time up to: 30 min(Determined at 2 µM substrate, using a P450 concentration of 10 pmol/ml)
Linear with P450 up to: 20 pmol/ml(Determined at 2 µM substrate, using an incubation time of 5 min)
Vmax: 2.5 pmol/min/pmol CYP
Km: 0.19 µM
Usage : For laboratory (research) purposes only.
Storage : Store at -80 centigrade. Avoid frequent temperature changes. Thaw on ice.
Concentration : P450 Concentration: 1.0 nmol/ml
Protein Concentration: 10.0 mg/ml
Specific P450 Content: 100 pmol/mg protein
Storage Buffer : 50 mM Tris-acetate (pH 7.6), 250 mM sucrose, 0.25 mM EDTA
Gene Name : CYP17A1 cytochrome P450 family 17 subfamily A member 1 [ Homo sapiens (human) ]
Official Symbol : CYP17A1
Synonyms : CYP17A1; cytochrome P450 family 17 subfamily A member 1; CPT7; CYP17; S17AH; P450C17; steroid 17-alpha-hydroxylase/17,20 lyase; 17-alpha-hydroxyprogesterone aldolase; CYPXVII; cytochrome P450 17A1; cytochrome P450, family 17, subfamily A, polypeptide 1; cytochrome P450, subfamily XVII (steroid 17-alpha-hydroxylase), adrenal hyperplasia; cytochrome P450-C17; cytochrome P450c17; cytochrome p450 XVIIA1; steroid 17-alpha-monooxygenase; EC; EC
Gene ID : 1586
mRNA Refseq : NM_000102
Protein Refseq : NP_000093
MIM : 609300
UniProt ID : P05093

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