Recombinant Human DIABLO Protein, Myc/DDK-tagged, C13 and N15-labeled

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Recombinant Human DIABLO Protein, Myc/DDK-tagged, C13 and N15-labeled

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Cat.No. : DIABLO-4238H
Product Overview : DIABLO MS Standard C13 and N15-labeled recombinant protein (NP_620308) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.
Description : This gene encodes an inhibitor of apoptosis protein (IAP)-binding protein. The encoded mitochondrial protein enters the cytosol when cells undergo apoptosis, and allows activation of caspases by binding to inhibitor of apoptosis proteins. Overexpression of the encoded protein sensitizes tumor cells to apoptosis. A mutation in this gene is associated with young-adult onset of nonsyndromic deafness-64. Alternative splicing results in multiple transcript variants encoding different isoforms.
Source : HEK293
Species : Human
Tag : Myc/DDK
Molecular Mass : 21.7 kDa
AA Sequence : MKSDFYFQKS EPHSLSSEAL MRRAVSLVTD STSTFLSQTT YALIEAITEY TKAVYTLTSL YRQYTSLLGK MNSEEEDEVW QVIIGARAEM TSKHQEYLKL ETTWMTAVGL SEMAAEAAYQ TGADQASITA RNHIQLVKLQ VEEVHQLSRK AETKLAEAQI EELRQKTQEE GEERAESEQE AYLREDTRTR PLEQKLISEE DLAANDILDY KDDDDKV
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 3 months from receipt of products under proper storage and handling conditions.
Storage : Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
Concentration : 50 μg/mL as determined by BCA
Storage Buffer : 100 mM glycine, 25 mM Tris-HCl, pH 7.3.
SDS-PAGE :

Gene Name : DIABLO diablo IAP-binding mitochondrial protein [ Homo sapiens (human) ]
Official Symbol : DIABLO
Synonyms : DIABLO; diablo, IAP-binding mitochondrial protein; diablo homolog, mitochondrial; DFNA64; DIABLO S; FLJ10537; FLJ25049; second mitochondria derived activator of caspase; SMAC; 0610041G12Rik; mitochondrial Smac protein; direct IAP-binding protein with low pI; second mitochondria-derived activator of caspase; SMAC3; DIABLO-S;
Gene ID : 56616
mRNA Refseq : NM_138930
Protein Refseq : NP_620308
MIM : 605219
UniProt ID : Q9NR28

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