Recombinant Human DLL3 protein, His-tagged

• Cat.No.: DLL3-31H
• Product Overview: Recombinant Human DLL3 (Ala27-Leu492) protein was fused to His-tag at C-terminus and expressed in human 293 cells (HEK293).

Specification

• Species: Human
• Source: HEK293
• Tag: His
• Protein Length: Ala27-Leu492
• Description: Delta-like protein 3 (DLL3) is a transmembrane protein that belongs to the Delta/Serrate/Lag-2 (DSL) family of Notch ligands.May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm. DLL3 protein is expressed on the surface of tumor cells but not in normal adult tissues.
• Predicted N Terminal: Ala27
• Form: Lyophilized from 0.22 μm filtered solution in PBS with Arginine, pH7.4, 10% trehalose.
• Molecular Mass: The protein has a calculated MW of 50.4 kDa. The protein migrates as 50-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
• Endotoxin: Less than 1.0 EU per μg by the LAL method.
• Purity: >90% as determined by SDS-PAGE.
• Storage: For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower.
  Please avoid repeated freeze-thaw cycles.
  This product is stable after storage at:
  -20 to -70 centigrade for 12 months in lyophilized state;
  -70 centigrade for 3 months under sterile conditions after reconstitution.
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents.
• Publications:
  The Special Role of JAK/STAT, and Notch Signaling Pathways in Cancer Pathogenesis (2023)

Gene Information

• Gene Name: DLL3
• Official Symbol: DLL3
• Synonyms: DLL3; delta-like 3 (Drosophila); delta (Drosophila) like 3; delta-like protein 3; SCDO1; delta3; drosophila Delta homolog 3
• Gene ID: 10683
• mRNA Refseq: NM_016941
• Protein Refseq: NP_058637
• MIM: 602768
• UniProt ID: Q9NYJ7