- Human(7)
Recombinant Human DOT1L protein, GST-tagged, Active
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| Cat.No. : | DOT1L-180H |
| Product Overview : | Recombinant Human DOT1L(1-435 aa) fused with GST tag at N-terminal was expressed in Insect cells. |
| Description : | DOT1-like protein (DOT1L) specifically methylates lysine-79 of histone H3 in the globular domain. DOT1L lacks a SET-domain, which is commonly considered to mediate lysine methylation of histones. DOT1 homologs exist in a variety of eukaryotic organisms. The activity of this methyltransferase is involved in cell cycle regulation and leukemogenesis. |
| Source : | Insect cells |
| Species : | Human |
| Tag : | GST |
| Form : | 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. |
| Bio-activity : | 14 nmol/min/mg |
| Molecular Mass : | 78 kDa |
| Protein length : | 1-435 aa |
| Purity : | >90% |
| Applications : | Methyltransferase Assay |
| Stability : | 1 year at -70 centigrade from the date of shipment |
| Storage : | Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
| Concentration : | 0.1μg/μl |
| Figure : |
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| Gene Name : | DOT1L DOT1-like, histone H3 methyltransferase (S. cerevisiae) [ Homo sapiens ] |
| Official Symbol : | DOT1L |
| Synonyms : | DOT1L; DOT1-like, histone H3 methyltransferase (S. cerevisiae); histone-lysine N-methyltransferase, H3 lysine-79 specific; DOT1; histone methyltransferase DOT1L; KIAA1814; KMT4; H3-K79-HMTase; DOT1-like protein; lysine N-methyltransferase 4; histone H3-K7 |
| Gene ID : | 84444 |
| mRNA Refseq : | NM_032482 |
| Protein Refseq : | NP_115871 |
| MIM : | 607375 |
| UniProt ID : | Q8TEK3 |
| Chromosome Location : | 19p13.3 |
| Pathway : | Lysine degradation, organism-specific biosystem; Lysine degradation, conserved biosystem; Transcriptional misregulation in cancer, organism-specific biosystem; Transcriptional misregulation in cancer, conserved biosystem; |
| Function : | DNA binding; histone-lysine N-methyltransferase activity; methyltransferase activity; protein binding; transcription factor binding; transferase activity; |
◆ Recombinant Protein
| DOT1L-2821H | Recombinant Human DOT1L Protein, GST-tagged | +Inquiry |
| DOT1L-006H | Recombinant Human DOT1L Protein, GST-tagged | +Inquiry |
| DOT1L-767H | Recombinant Human DOT1L, None tagged | +Inquiry |
| DOT1L-658H | Recombinant Human DOT1L, GST-tagged | +Inquiry |
| DOT1L-27742TH | Recombinant Human DOT1L | +Inquiry |
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◆ Lysates
| DOT1L-6841HCL | Recombinant Human DOT1L 293 Cell Lysate | +Inquiry |
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