Recombinant Human DOT1L protein, GST-tagged, Active DOT1L-180H

Recombinant Human DOT1L protein, GST-tagged, Active


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Recombinant Human DOT1L protein, GST-tagged, Active

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Cat.No. : DOT1L-180H
Product Overview : Recombinant Human DOT1L(1-435 aa) fused with GST tag at N-terminal was expressed in Insect cells.
Description : DOT1-like protein (DOT1L) specifically methylates lysine-79 of histone H3 in the globular domain. DOT1L lacks a SET-domain, which is commonly considered to mediate lysine methylation of histones. DOT1 homologs exist in a variety of eukaryotic organisms. The activity of this methyltransferase is involved in cell cycle regulation and leukemogenesis.
Source : Insect cells
Species : Human
Tag : GST
Form : 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Bio-activity : 14 nmol/min/mg
Molecular Mass : 78 kDa
Protein length : 1-435 aa
Purity : >90%
Applications : Methyltransferase Assay
Stability : 1 year at -70 centigrade from the date of shipment
Storage : Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Concentration : 0.1μg/μl
Figure :

Gene Name : DOT1L DOT1-like, histone H3 methyltransferase (S. cerevisiae) [ Homo sapiens ]
Official Symbol : DOT1L
Synonyms : DOT1L; DOT1-like, histone H3 methyltransferase (S. cerevisiae); histone-lysine N-methyltransferase, H3 lysine-79 specific; DOT1; histone methyltransferase DOT1L; KIAA1814; KMT4; H3-K79-HMTase; DOT1-like protein; lysine N-methyltransferase 4; histone H3-K7
Gene ID : 84444
mRNA Refseq : NM_032482
Protein Refseq : NP_115871
MIM : 607375
UniProt ID : Q8TEK3
Chromosome Location : 19p13.3
Pathway : Lysine degradation, organism-specific biosystem; Lysine degradation, conserved biosystem; Transcriptional misregulation in cancer, organism-specific biosystem; Transcriptional misregulation in cancer, conserved biosystem;
Function : DNA binding; histone-lysine N-methyltransferase activity; methyltransferase activity; protein binding; transcription factor binding; transferase activity;

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