| Cat.No. : |
EGFR-024HAF488
Optional Service: Optional requirements on this protein
|
| Product Overview : |
Alexa Fluor 488 conjugated recombinant human EGFR Fc Chimera(rhEGFR-Fc) Met1-Lys642 (Accession # NP_005219) was expressed in human 293 cells (HEK293). |
| Description : |
The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. [provided by RefSeq, Jun 2016] |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Fc |
| Molecular Mass : |
rhEGFR-Fc is a homodimeric protein and is fused with the Fc region of human IgG1 at the C-terminus. The reduced monomer consists of 860 amino acids and has a calculated molecular mass of 95 kDa. In DTT-reduced SDS-PAGE, protein migrates as 130-140 kDa. |
| Protein length : |
860 |
| N-terminal Sequence Analysis : |
Leu 25 |
| Endotoxin : |
< 0.01 ng endotoxin/1 μg rhEGFR-Fc. |
| Purity : |
> 95 % as determined by SDS-PAGE |
| Characteristic : |
Disulfide-linked homodimer
Labeled with Alexa Fluor 488 via amines
Excitation Wavelength: 488 nm
Emission Wavelength: 515-545 nm |
| Storage : |
Store at -20 centigrade in lyophilized state after receipt. For long term storage, upon reconstitution rhEGFR-Fc should be aliquot and store at -20 centigrade or -8 centigrade centigrade. Avoid repeated freeze-thaw cycles. |
| Storage Buffer : |
Bulk protein in a 0.22 μm filtered solution of PBS, pH 7.4 and delivered as liquid formulation or lyophilized powder. Normally 5-8% trehalose and mannitol are added as protectants before lyophilization. |
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
