Recombinant Human EIF2AK2 Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: EIF2AK2-2983H
• Product Overview: EIF2AK2 MS Standard C13 and N15-labeled recombinant protein (NP_001129123) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. Three transcript variants encoding two different isoforms have been found for this gene.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 62.1 kDa
• AA Sequence: MAGDLSAGFFMEELNTYRQKQGVVL KYQELPNSGPPHDRRFTFQVIIDGR EFPEGEGRSKKEAKNAAAKLAVEIL NKEKKAVSPLLLTTTNSSEGLSMGN YIGLINRIAQKKRLTVNYEQCASGV HGPEGFHYKCKMGQKEYSIGTGSTK QEAKQLAAKLAYLQILSEETSVKSD YLSSGSFATTCESQSNSLVTSTLAS ESSSEGDFSADTSEINSNSDSLNSS SLLMNGLRNNQRKAKRSLAPRFDLP DMKETKYTVDKRFGMDFKEIELIGS GGFGQVFKAKHRIDGKTYVIKRVKY NNEKAEREVKALAKLDHVNIVHYNG CWDGFDYDPETSDDSLESSDYDPEN SKNSSRSKTKCLFIQMEFCDKGTLE QWIEKRRGEKLDKVLALELFEQITK GVDYIHSKKLIHRDLKPSNIFLVDT KQVKIGDFGLVTSLKNDGKRTRSKG TLRYMSPEQISSQDYGKEVDLYALG LILAELLHVCDTAFETSKFFTDLRD GIISDIFDKKEKTLLQKLLSKKPED RPNTSEILRTLTVWKKSPEKNERHT CTRTRPLEQKLISEEDLAANDILDY KDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 [ Homo sapiens (human) ]
• Official Symbol: EIF2AK2
• Synonyms: EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2; PRKR, protein kinase, interferon inducible double stranded RNA dependent; interferon-induced, double-stranded RNA-activated protein kinase; EIF2AK1; PKR; p68 kinase; eIF-2A protein kinase 2; P1/eIF-2A protein kinase; tyrosine-protein kinase EIF2AK2; interferon-inducible elF2alpha kinase; double stranded RNA activated protein kinase; protein kinase, interferon-inducible double stranded RNA dependent; PRKR; MGC126524
• Gene ID: 5610
• mRNA Refseq: NM_001135651
• Protein Refseq: NP_001129123
• MIM: 176871
• UniProt ID: P19525