| Description : |
Ectonucleotide pyrophosphatase/phosphodiesterase 3 (ENPP3/CD203c/PD-Ιbeta) is a type-II transmembrane glycoprotein that contains a large extracellular domain, an α-helical transmembrane segment, and a short cytoplasmic domain containing the N-terminus. ENPP3 has been shown to be overexpressed in colon carcinoma and is thought to play a role in tumor initiation and tumor cell invasiveness. Within the hematopoietic cell compartment, ENPP3 is a cell surface marker of basophil and mast cell lineages. Indeed, ENPP3 is overexpressed on transformed mast cells in patients with systemic mastocytosis. Recently, ENPP3 has been identified as being highly overexpressed in renal cell carcinoma (RCC) and may have potential as a novel therapeutic target for this disease. |
| Source : |
E. coli |
| Species : |
Human |
| Tag : |
His |
| Molecular Mass : |
~110 kDa |
| AA Sequence : |
MLLVIMSLGLGLGLGLRKLEKQGSC RKKCFDASFRGLENCRCDVACKDRG DCCWDFEDTCVESTRIWMCNKFRCG ETRLEASLCSCSDDCLQRKDCCADY KSVCQGETSWLEENCDTAQQSQCPE GFDLPPVILFSMDGFRAEYLYTWDT LMPNINKLKTCGIHSKYMRAMYPTK TFPNHYTIVTGLYPESHGIIDNNMY DVNLNKNFSLSSKEQNNPAWWHGQP MWLTAMYQGLKAATYFWPGSEVAIN GSFPSIYMPYNGSVPFEERISTLLK WLDLPKAERPRFYTMYFEEPDSSGH AGGPVSARVIKALQVVDHAFGMLME GLKQRNLHNCVNIILLADHGMDQTY CNKMEYMTDYFPRINFFYMYEGPAP RIRAHNIPHDFFSFNSEEIVRNLSC RKPDQHFKPYLTPDLPKRLHYAKNV RIDKVHLFVDQQWLAVRSKSNTNCG GGNHGYNNEFRSMEAIFLAHGPSFK EKTEVEPFENIEVYNLMCDLLRIQP APNNGTHGSLNHLLKVPFYEPSHAE EVSKFSVCGFANPLPTESLDCFCPH LQNSTQLEQVNQMLNLTQEEITATV KVNLPFGRPRVLQKNVDHCLLYHRE YVSGFGKAMRMPMWSSYTVPQLGDT SPLPPTVPDCLRADVRVPPSESQKC SFYLADKNITHGFLYPPASNRTSDS QYDALITSNLVPMYEEFRKMWDYFH SVLLIKHATERNGVNVVSGPIFDYN YDGHFDAPDEITKHLANTDVPIPTH YFVVLTSCKNKSHTPENCPGWLDVL PFIIPHRPTNVESCPEGKPEALWVE ERFTAHIARVRDVELLTGLDFYQDK VQPVSEILQLKTYLPTFETTI |
| Purity : |
Transferred into competent cells and the supernatant was purified by NI column affinity chromatography and the purity is > 85% (by SDS-PAGE). |
| Notes : |
For research use only, not for use in diagnostic procedure. |
| Storage : |
Store at 4 centigrade short term. Aliquot and store at -20 centigrade long term. Avoid freeze-thaw cycles. |
| Storage Buffer : |
PBS, 4M Urea, pH7.4 |
