Recombinant Human EWSR1 Protein, GST-tagged

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Recombinant Human EWSR1 Protein, GST-tagged

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Cat.No. : EWSR1-3553H
Product Overview : Human EWSR1 partial ORF ( NP_005234, 358 a.a. - 453 a.a.) recombinant protein with GST-tag at N-terminal.
Description : This gene encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. The protein includes an N-terminal transcriptional activation domain and a C-terminal RNA-binding domain. Chromosomal translocations between this gene and various genes encoding transcription factors result in the production of chimeric proteins that are involved in tumorigenesis. These chimeric proteins usually consist of the N-terminal transcriptional activation domain of this protein fused to the C-terminal DNA-binding domain of the transcription factor protein. Mutations in this gene, specifically a t(11;22)(q24;q12) translocation, are known to cause Ewing sarcoma as well as neuroectodermal and various other tumors. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and 14. [provided by RefSeq, Jul 2009]
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 36.3 kDa
AA Sequence : SDNSAIYVQG LNDSVTLDDL ADFFKQCGVV KMNKRTGQPM IHIYLDKETG KPKGDATVSY EDPPTAKAAV EWFDGKDFQG SKLKVSLARK KPPMNS
Applications : Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Quality Control Testing :

12.5% SDS-PAGE Stained with Coomassie Blue.

Gene Name : EWSR1 Ewing sarcoma breakpoint region 1 [ Homo sapiens ]
Official Symbol : EWSR1
Synonyms : EWSR1; Ewing sarcoma breakpoint region 1; RNA-binding protein EWS; EWS; Ewings sarcoma EWS-Fli1 (type 1) oncogene; bK984G1.4;
Gene ID : 2130
mRNA Refseq : NM_001163285
Protein Refseq : NP_001156757
MIM : 133450
UniProt ID : Q01844

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