Recombinant Human FAP Protein, His-tagged
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Cat.No. : | FAP-006H Optional Service: Optional requirements on this protein |
Product Overview : | Recombinant human FAP, fused to His-tag at C-terminus, was expressed in insert cell and purified by using conventional chromatography techniques. |
Description : | The protein encoded by this gene is a homodimeric integral membrane gelatinase belonging to the serine protease family. It is selectively expressed in reactive stromal fibroblasts of epithelial cancers, granulation tissue of healing wounds, and malignant cells of bone and soft tissue sarcomas. This protein is thought to be involved in the control of fibroblast growth or epithelial-mesenchymal interactions during development, tissue repair, and epithelial carcinogenesis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
Source : | Insect cells |
Species : | Human |
Tag : | His |
Form : | Liquid |
Bio-activity : | Specific activity is > 5,000 pmol/min/μg, and is defined as the amount of enzyme that hydrolysis 1.0 pmole of Z-GP-AMC per minute at pH 7.5, at 37 centigrade. |
Molecular Mass : | 86.1 kDa |
AA Sequence : | <ADP>LRPSR VHNSEENTMR ALTLKDILNG TFSYKTFFPN WISGQEYLHQ SADNNIVLYN IETGQSYTIL SNRTMKSVNA SNYGLSPDRQ FVYLESDYSK LWRYSYTATY YIYDLSNGEF VRGNELPRPI QYLCWSPVGS KLAYVYQNNI YLKQRPGDPP FQITFNGREN KIFNGIPDWV YEEEMLATKY ALWWSPNGKF LAYAEFNDTD IPVIAYSYYG DEQYPRTINI PYPKAGAKNP VVRIFIIDTT YPAYVGPQEV PVPAMIASSD YYFSWLTWVT DERVCLQWLK RVQNVSVLSI CDFREDWQTW DCPKTQEHIE ESRTGWAGGF FVSTPVFSYD AISYYKIFSD KDGYKHIHYI KDTVENAIQI TSGKWEAINI FRVTQDSLFY SSNEFEEYPG RRNIYRISIG SYPPSKKCVT CHLRKERCQY YTASFSDYAK YYALVCYGPG IPISTLHDGR TDQEIKILEE NKELENALKN IQLPKEEIKK LEVDEITLWY KMILPPQFDR SKKYPLLIQV YGGPCSQSVR SVFAVNWISY LASKEGMVIA LVDGRGTAFQ GDKLLYAVYR KLGVYEVEDQ ITAVRKFIEM GFIDEKRIAI WGWSYGGYVS SLALASGTGL FKCGIAVAPV SSWEYYASVY TERFMGLPTK DDNLEHYKNS TVMARAEYFR NVDYLLIHGT ADDNVHFQNS AQIAKALVNA QVDFQAMWYS DQNHGLSGLS TNHLYTHMTH FLKQCFSLSD <HHHHHH> |
Endotoxin : | < 1 EU/μg of protein (determined by LAL method) |
Purity : | > 90% by SDS-PAGE |
Applications : | SDS-PAGE, Enzyme Activity |
Storage : | Can be stored at +2 to +8 centigrade for 1 week. For long term storage, aliquot and store at -20 to -85 centigrade. Avoid repeated freezing and thawing cycles. |
Concentration : | 0.25 mg/mL (determined by absorbance at 280nm) |
Storage Buffer : | Phosphate-Buffered Saline (pH 7.4) containing 20% glycerol |
SDS-PAGE : |
![]() 3 μg by SDS-PAGE under reducing condition and visualized by coomassie blue stain |
Gene Name : | FAP fibroblast activation protein alpha [ Homo sapiens (human) ] |
Official Symbol : | FAP |
Synonyms : | FAP; fibroblast activation protein alpha; FAPA; SIMP; DPPIV; FAPalpha; prolyl endopeptidase FAP; 170 kDa melanoma membrane-bound; gelatinase; dipeptidyl peptidase FAP; gelatine degradation protease FAP; integral membrane serine protease; post-proline cleaving enzyme; seprase; surface-expressed protease; EC 3.4.14.5; EC 3.4.21.26 |
Gene ID : | 2191 |
mRNA Refseq : | NM_004460 |
Protein Refseq : | NP_004451.2 |
MIM : | 600403 |
UniProt ID : | Q12884 |
◆ Recombinant Protein
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Fap-1018M | Recombinant Mouse Fap Protein, MYC/DDK-tagged | +Inquiry |
Fap-716M | Recombinant Mouse Fap Protein, His-tagged | +Inquiry |
FAP-3836H | Recombinant Human FAP Protein, GST-tagged | +Inquiry |
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◆ Lysates
FAP-1881HCL | Recombinant Human FAP cell lysate | +Inquiry |
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◆ Assay kits
Kit-1729 | FAP Assay Kit | +Inquiry |
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