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Recombinant Human FGF2 Protein, His-tagged

Cat.No. : FGF2-001H
Product Overview : Recombinant Human FGF2 Protein (134-288 aa (isoform 18kDa)) with 6xHis tag was expressed in E. coli.
Availability February 16, 2025
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Description : The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for this gene contains multiple polyadenylation sites, and is alternatively translated from non-AUG (CUG) and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF.
Source : E. coli
Species : Human
Tag : His
Molecular Mass : 18.3 kDa
Protein length : 134-288
Purity : >90% confirmed by 10% SDS-PAGE stained with Coomassie Blue (CB), immunobloting with anti-6xHis (WB).
Applications : ELISA, Western Blot, Antibody Production, Protein array
Quality Control Test : 10% SDS-PAGE stained with Coomassie Blue (CB), immunobloting with anti-6His (WB) and peptide fingerprinting by MALDI-TOF mass spectrometry.
Storage : Prior to reconstitution, store the lyophilized protein at 2−8 centigrade. After reconstitution, store in working aliquots at −80 centigrade.
Expiry : All components are stable for 1 year of receipt, if stored properly.
Storage Buffer : Lyophilized from a solution containing 20mM Sodium Phosphate, 0.15M NaCl, 0.5M Imidzole, pH 7,4.
Shipping : Lyophilized at Ambient temperature
Gene Name : FGF2 fibroblast growth factor 2 [ Homo sapiens (human) ]
Official Symbol : FGF2
Synonyms : FGF2; fibroblast growth factor 2; BFGF; FGFB; FGF-2; HBGF-2; fibroblast growth factor 2; basic fibroblast growth factor Bfgf; fibroblast growth factor 2 (basic); heparin-binding growth factor 2; prostatropin
Gene ID : 2247
mRNA Refseq : NM_002006
Protein Refseq : NP_001997
MIM : 134920
UniProt ID : P09038

Not For Human Consumption!

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07/14/2022

    The technical expert communicated with me in time to understand the progress of my experiment and gave me suggestions for improvement.

    02/04/2022

      The purchased protein is suitable for WB experiments and I am satisfied with the results.

      Q&As (6)

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      What is the biological function of FGF2? 11/10/2022

      FGF2 promotes cell migration and angiogenesis and regulates bone homeostatic balance.

      Where is FGF2 mainly expressed? 10/22/2022

      FGF2 is widely expressed in the nervous system.

      In which tissues of sheep is FGF2 primarily expressed? 01/01/2022

      FGF2 is mainly expressed in tissues such as mammary glands and ovaries of sheep.

      What protein does FGF2 share high homology with? 03/08/2021

      FGF1 has a high degree of homology with FGF2.

      What diseases is FGF2 involved in? 02/12/2021

      FGF2 is involved in diseases such as cardiovascular disease, breast disease and bone homeostasis.

      How does FGF2 regulate bone homeostasis? 11/21/2020

      FGF2 negatively regulates bone homeostasis.

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