|Product Overview:||Human FGFR3 (NP_000133.1, 436 a.a. - 806 a.a.) partial recombinant protein with GST tag expressed in baculovirus infected Sf21 cells.|
|Description:||This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia. Three alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq|
|Bio-activity:||The activity was measured by off-chip mobility shift assay. The enzyme was incubated with fluorescence-labeled substrate and Mg(or Mn)/ATP. The phosphorylated and unphosphorylated substrates were separated and detected by LabChip 3000.
ATP: 100 μM.
|Molecular Mass:||68 kDa|
|Purity:||74 % by SDS-PAGE/CBB staining|
|Storage:||Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.|
|Storage Buffer:||In 50 mM Tris-HCl, 150 mM NaCl, pH 7.5 (0.1% CHAPS, 1 mM DTT, 10% glycerol)|
|Gene Name:||FGFR3 fibroblast growth factor receptor 3 [ Homo sapiens ]|
|Synonyms:||FGFR3; fibroblast growth factor receptor 3; ACH, achondroplasia, thanatophoric dwarfism; CD333; CEK2; JTK4; FGFR-3; tyrosine kinase JTK4; hydroxyaryl-protein kinase; ACH; HSFGFR3EX;|