Recombinant Human FLT3, GST-tagged, Active
Cat.No. : | FLT3-319H |
Product Overview : | Recombinant human FLT3 (571-993) was expressed by baculovirus inSf9 cellsusing an N-terminal GST tag. MW=73kDa. |
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Species : | Human |
Source : | Sf9 Cells |
Tag : | GST |
ProteinLength : | 571-993 a.a. |
Description : | FLT3 is a receptor tyrosine kinase that has been shown to play a role in proliferation and survival of hematopoietic progenitor cells as well as differentiation of early B lymphoid progenitors. FLT3 consists of an extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. FLT3 is the most frequently mutated gene in cases of acute myelogenous leukemia (AML). About 30 to 35% of patients have either internal tandem duplications (ITDs) in the juxtamembrane domain or mutations in the activating loop of FLT3. The consequence of either FLT3-ITD or activating loop mutations is the constitutive activation of the tyrosine kinase activity. |
Sequence : | 571-993. |
Applications : | Kinase Assay, Western Blot. |
Storage And Stability : | Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
Gene Name | FLT3 fms-related tyrosine kinase 3 [ Homo sapiens ] |
Synonyms | FLT3; fms-related tyrosine kinase 3; FLK2; STK1; CD135; CD135 antigen; fetal liver kinase 2; FL cytokine receptor; tal liver kinase 2; stem cell tyrosine kinase 1; FLT3 receptor tyrosine kinase; tyrosine-protein kinase receptor FLT3; growth factor receptor tyrosine kinase type III; C 2.7.10.1; OTTHUMP00000042340; fetal liver kinase 2 |
Gene ID | 2322 |
mRNA Refseq | NM_004119 |
Protein Refseq | NP_004110 |
UniProt ID | P36888 |
Chromosome Location | 13q12 |
MIM | 136351 |
Pathway | ute myeloid leukemia; Cytokine-cytokine receptor interaction; Hematopoietic cell lineage; Pathways in cancer |
Function | ATP binding; nucleotide binding; osphoinositide 3-kinase binding; protein binding; receptor activity; transferase activity; vascular endothelial growth factor receptor activity |
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Not For Human Consumption!
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