Recombinant Human FLT3LG, His-tagged

• Cat.No.: FLT3LG-28341TH
• Product Overview: Recombinant fragment, corresponding to amino acids 27-181 of Human Flt3 ligand with His tag produced in the endosperm tissue of barley grain ; 156 amino acids, 19.8 kDa.

Specification

• Species: Human
• Tag: His
• Protein Length: 27-181 a.a.
• Description: Dendritic cells (DCs) provide the key link between innate and adaptive immunity by recognizing pathogens and priming pathogen-specific immune responses. FLT3LG controls the development of DCs and is particularly important for plasmacytoid DCs and CD8 (see MIM 186910)-positive classical DCs and their CD103 (ITGAE; MIM 604682)-positive tissue counterparts (summary by Sathaliyawala et al.
• Conjugation: HIS
• Biological activity: Bioactivity:The EC50 for FLT3LG-28341TH lies in the range of 0.12-0.18 ng/ml, corresponding to specific activity 6.62 x 106 U/mg. We recommend that the optimal concentration for each specific application be determined by an initial dose-response assay.
• Form: Lyophilised:It is recommended to reconstitute the lyophilized protein in sterile phosphate-buffered saline to a concentration of no less than 100 μg/ml. For long term storage of the reconstituted solution it is recommended to add a carrier protein (0.1% H
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 10mM Acetic acid, pH 5.0
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.

Gene Information

• Gene Name: FLT3LG fms-related tyrosine kinase 3 ligand [ Homo sapiens ]
• Official Symbol: FLT3LG
• Synonyms: FLT3LG; fms-related tyrosine kinase 3 ligand
• Gene ID: 2323
• mRNA Refseq: NM_001204502
• Protein Refseq: NP_001191431
• MIM: 600007
• Uniprot ID: P49771
• Chromosome Location: 19q13.3
• Pathway: Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Hematopoietic cell lineage, organism-specific biosystem; Hematopoietic cell lineage, conserved biosystem; Pathways in cancer, organism-specific biosystem
• Function: cytokine activity; receptor binding